Value of serum NT proBNP, HMGB1, and SIRT1 in the diagnosis and prognosis of neonatal respiratory distress syndrome.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-04-01 DOI:10.12669/pjms.41.4.10095

Qingqing Yang, Hongbin Zhu

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引用次数: 0

Abstract

Objective: To analyze the value of serum aminoterminal pro-brain natriuretic peptide (NT-proBNP), High mobility group protein B1(HMGB1), and silent information regulator factor 2 related enzyme 1 (SIRT1) in the diagnosis and prognosis of neonatal respiratory distress syndrome (NRDS).

Methods: This was a retrospective study. Eighty cases of NRDS infants were selected in Maternity & Child Care Center of Qinhuangdao from January 2022 to January 2024 as the study group, with 80 cases of normal newborns during the same period selected as the control group. The NRDS infants were divided into the excellent prognosis group (n=49) and the poor prognosis group (n=31). The levels of serum NT-proBNP, HMGB1, and SIRT1 were compared among the groups, along with an investigation of the value of these biomarkers for the diagnosis and prognosis of NRDS infants.

Results: The study group exhibited higher levels of serum NT-proBNP and HMGB1(P< 0.05) and lower levels of serum SIRT1(P< 0.05) than the control group. The ROC curve analysis suggested that AUC values for serum NT-proBNP, HMGB1, SIRT1, and their combination in the diagnosis of NRDS were 0.903, 0.829, 0.794, and 0.958, respectively. The ROC curve analysis showed that AUC values for serum NT-proBNP, HMGB1, SIRT1, and their combination in predicting poor prognosis in NRDS infants were 0.810, 0.813, 0.741, and 0.935, respectively.

Conclusion: The combination of serum NT-proBNP, HMGB1, and SIRT1 may demonstrate a high diagnostic value for NRDS infants, as well as a high predictive value for poor prognosis in such infants.

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血清NT proBNP、HMGB1、SIRT1在新生儿呼吸窘迫综合征诊断及预后中的价值

目的：分析血清氨基末端前脑利钠肽（NT-proBNP）、高迁移率组蛋白B1（HMGB1）、沉默信息调节因子2相关酶1（SIRT1）在新生儿呼吸窘迫综合征（NRDS）诊断及预后中的价值。方法：回顾性研究。选择2022年1月至2024年1月在秦皇岛妇幼保健中心出生的80例NRDS患儿作为研究组，80例同期正常新生儿作为对照组。将NRDS患儿分为预后优良组（n=49）和预后不良组（n=31）。比较各组间血清NT-proBNP、HMGB1和SIRT1水平，并探讨这些生物标志物对NRDS患儿诊断和预后的价值。结果：研究组患者血清NT-proBNP、HMGB1水平高于对照组（P< 0.05）， SIRT1水平低于对照组（P< 0.05）。ROC曲线分析显示，血清NT-proBNP、HMGB1、SIRT1及其联合诊断NRDS的AUC值分别为0.903、0.829、0.794、0.958。ROC曲线分析显示，血清NT-proBNP、HMGB1、SIRT1及其联合预测NRDS患儿预后不良的AUC值分别为0.810、0.813、0.741、0.935。结论：血清NT-proBNP、HMGB1、SIRT1联合检测对NRDS患儿具有较高的诊断价值，对NRDS患儿预后不良具有较高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.