Shuo Wang, Dewen Xu, Lin Ji, Yulong Liu, Yunhai Zhang, Xin Miao
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引用次数: 0
Abstract
This study aims to develop a portable reflective confocal microscope (PCRM) based on MEMS micro-mirrors for in vivo skin imaging. The design of PCRM is intended to overcome the limitations of traditional invasive biopsies and bulky desktop microscopes, enabling handheld operation and access to hard-to-reach skin areas. This research innovatively integrates MEMS technology into the PCM through precise mechanical design, using an 830 nm laser and a commercial Olympus objective lens, achieving a lateral resolution of 1.24 μm and an axial resolution of 5.3 μm, with imaging at a speed of 11 f/s over a field of view of 530 × 500 μm. PCRM successfully imaged various skin layers, including capillary blood flow, demonstrating diagnostic potential for skin lesions and providing a compact, high-performance solution for non-invasive skin imaging suitable for clinical applications.
期刊介绍：
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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