Liver-stage malaria transcriptomes: what you don't know can kill you.

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI:10.1016/j.pt.2025.04.003

Patrick E Duffy, Moriya Tsuji

引用次数: 0

Abstract

The Plasmodium liver-stage (LS) represents a promising target for malaria vaccine and drug development, as LS elimination prevents progression to symptomatic blood-stage (BS) infection and subsequent parasite transmission. Comprehensive LS gene expression profiles remain unexplored. Zanghi et al. report successful transcriptomic analysis of human malaria LS throughout intrahepatocytic development.

查看原文本刊更多论文

肝期疟疾转录组：你不知道的东西可以杀死你。

肝期疟原虫（LS）是疟疾疫苗和药物开发的一个有希望的目标，因为消除LS可防止进展为有症状的血期疟原虫（BS）感染和随后的寄生虫传播。全面的LS基因表达谱仍未被探索。Zanghi等人报道了人类疟疾LS在肝内细胞发育过程中的成功转录组学分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.