Cancer risk according to lifestyle risk score trajectories: a population-based cohort study.

BJC reports Pub Date : 2025-04-25 DOI:10.1038/s44276-025-00141-6

Thi Minh Thu Khong, Thi Tra Bui, Hee-Yeon Kang, Eunjung Park, Moran Ki, Yoon-Jung Choi, Byungmi Kim, Jin-Kyoung Oh

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Abstract

Background: While individual lifestyle behaviors have been associated with cancer risk, combined impact of these factors remains understudied. This research explores relationships between lifestyle risk score trajectories and cancer risk within the Korean population.

Methods: A cohort of 3,451,189 cancer-free men and women who participated in a health examination between 2002 and 2003, provided by the National Health Insurance, was studied. Lifestyle risk score trajectories were determined using group-based trajectory modeling based on total score of four modifiable unhealthy behaviors: current smoking, heavy alcohol drinking, excess body weight, and physical inactivity repeatedly observed three times between 2002 and 2007. Scores ranged between 0 (low risk) and 8 (high risk). The Cox proportional hazards model was applied to examine the association between these trajectories and cancer incidence.

Results: During the follow-up time (2008-2019), 312,075 cancer cases were identified. Among men, seven trajectories were identified, and trajectories of high lifestyle risk scores increased cancer risk of all cancer combined, cancer subgroupings, upper aero-digestive, stomach, colorectal, liver, gallbladder, pancreatic, lung, and bladder cancer, but inverse relation was observed for prostate cancer. Among women, four trajectory groups showed similar trends.

Conclusions: Maintaining a healthy lifestyle and avoiding unhealthy behaviors are essential for cancer prevention.

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基于生活方式风险评分轨迹的癌症风险：一项基于人群的队列研究

背景：虽然个人生活方式行为与癌症风险有关，但这些因素的综合影响仍未得到充分研究。这项研究探讨了韩国人口中生活方式风险评分轨迹与癌症风险之间的关系。方法：对2002年至2003年期间参加国家健康保险提供的健康检查的3,451,189名无癌症男性和女性进行了研究。生活方式风险评分轨迹采用基于组的轨迹模型确定，该模型基于四种可改变的不健康行为的总分：当前吸烟、大量饮酒、超重和缺乏身体活动，在2002年至2007年期间重复观察了三次。得分范围在0（低风险）到8（高风险）之间。应用Cox比例风险模型来检验这些轨迹与癌症发病率之间的关系。结果：在随访期间（2008-2019年），共发现312075例癌症病例。在男性中，确定了7个轨迹，高生活方式风险评分的轨迹增加了所有癌症，癌症亚组，上航空消化道，胃癌，结肠直肠癌，肝癌，胆囊癌，胰腺癌，肺癌和膀胱癌的癌症风险，但与前列腺癌呈反比关系。在女性中，四个轨迹组显示出类似的趋势。结论：保持健康的生活方式，避免不健康的行为对预防癌症至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BJC reports

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