Safeguarding genomic imprints in naive human pluripotency.

IF 5.1 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Reports Pub Date : 2025-05-13 Epub Date: 2025-04-17 DOI:10.1016/j.stemcr.2025.102475

Alejandro De Los Angeles

引用次数: 0

Abstract

Naive human pluripotent stem cells (hPSCs) closely mirror the pre-implantation epiblast but risk imprint erosion under strong MEK/ERK inhibition, jeopardizing disease modeling and regenerative applications. In Stem Cell Reports, Fischer et al. show that partial MEK/ERK inhibition plus ZFP57 overexpression crucially preserves parent-of-origin DNA methylation, thereby offering more faithful and stable naive hPSC models.

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保护人类多能性的基因组印记。

幼稚的人类多能干细胞（hPSCs）与植入前的外胚层非常相似，但在MEK/ERK的强烈抑制下存在印记侵蚀的风险，危及疾病建模和再生应用。在干细胞报告中，Fischer等人表明，部分MEK/ERK抑制加上ZFP57过表达至关重要地保留了亲本来源的DNA甲基化，从而提供了更忠实和稳定的初始hPSC模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

10.50

自引率

1.70%

发文量

200

审稿时长

28 weeks

期刊介绍： Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.