Impact of obstructive sleep apnea on hematocrit levels and erythrocytosis - a clinical study.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2025-05-09 DOI:10.1007/s11325-025-03330-2

Patrícia Guerra, Daniel Alfaiate, Nuno Pinto, Telmo Pereira, Alexandre Pereira

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引用次数: 0

Abstract

Objective: Assess differences between hematocrit levels in a population with and without obstructive sleep apnea (OSA) and determine if these differences correlate with disease severity and/or with levels of hypoxemia.

Material and methods: Data was collected from patients who underwent level I polysomnography (PSG) in the sleep laboratory at Hospital Rainha Santa Isabel, Torres Novas, Portugal, between January 2018 and December 2022. The patients' medical data was analyzed and sociodemographic (gender, body mass index (BMI) and age), polysomnographic (Apnea and Hypopnea Index (AHI), mean SpO2, minimum SpO2, Oxygen Desaturation Index (ODI), T90 and T85) and laboratory data (hematocrit (HCT), hemoglobin (HGB) and erythrocyte count) were collected. Statistical analysis included one-way ANOVA with Tukey's HSD for pairwise comparisons, Pearson's correlation for associations between polysomnographic and hematological parameters, and multivariate regression to identify independent factors.

Results: HCT levels were found to be higher in the moderate OSA group, particularly compared to the no OSA group (42.34 ± 4.09% vs 40.28 ± 2.75%), with significant differences between groups (p = 0.032). Although HCT levels were shown to be higher in the OSA group, the mean values remained within normal range, so no patient manifested erythrocytosis.

Conclusion: Our results suggest that moderate OSA is associated with increased HCT levels but does not seem to cause secondary erythrocytosis. Future research should further evaluate the hypoxic burden of OSA, as increased HCT may raise the risk of cardiovascular complications.

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阻塞性睡眠呼吸暂停对红细胞压积水平和红细胞增多的影响-一项临床研究。

目的：评估阻塞性睡眠呼吸暂停（OSA）患者和非OSA患者红细胞压积水平的差异，并确定这些差异是否与疾病严重程度和/或低氧血症水平相关。材料和方法：数据收集自2018年1月至2022年12月期间在葡萄牙托雷斯诺瓦斯的Rainha Santa Isabel医院睡眠实验室接受I级多导睡眠图（PSG）检查的患者。分析患者的医疗资料，收集社会人口学（性别、体重指数（BMI）和年龄）、多导睡眠图（呼吸暂停和低通气指数（AHI）、平均SpO2、最低SpO2、氧去饱和指数（ODI）、T90和T85）和实验室数据（红细胞压积（HCT）、血红蛋白（HGB）和红细胞计数）。统计分析包括单因素方差分析，用Tukey’s HSD进行两两比较，用Pearson’s相关性分析多导睡眠图和血液学参数之间的关系，用多因素回归来确定独立因素。结果：中度OSA组HCT水平明显高于无OSA组（42.34±4.09% vs 40.28±2.75%），组间差异有统计学意义（p = 0.032）。虽然OSA组HCT水平较高，但平均值仍在正常范围内，故未见患者出现红细胞增多。结论：我们的研究结果表明，中度OSA与HCT水平升高有关，但似乎不会引起继发性红细胞增多。未来的研究应进一步评估OSA的缺氧负担，因为HCT升高可能会增加心血管并发症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.