Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2025-04-17 DOI:10.1007/s11325-025-03324-0

Kostas Archontogeorgis, Athanasios Voulgaris, Konstantina Chadia, Konstantinos Bonelis, Paschalis Steiropoulos

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引用次数: 0

Abstract

Purpose: Vitamin D (Vit D) deficiency has been associated with both obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) as well as with their combination, known as overlap syndrome (OS). There is evidence that continuous positive airway pressure (CPAP) may lead to an increase of Vit D levels in OSA patients. However, the effect of CPAP treatment on Vit D levels in OS patients has yet to be determined. The aim of the present study was to investigate the effect of one year of CPAP therapy on Vit D levels in patients with OS.

Methods: Vit D serum levels were measured in consecutive OS patients at baseline and after one year of CPAP therapy. Compliance with CPAP therapy was assessed by the data retrieved from the CPAP device.

Results: Vit D serum levels were measured in 46 OS patients (43 males). Among participants, 27 had good and 19 poor compliance with CPAP therapy. Results showed that serum Vit D levels increased after 12 months of CPAP therapy from 21.3 ± 8.4 to 23.8 ± 8.7 ng/ml (p = 0.001). Moreover, patients with good CPAP compliance demonstrated higher serum 25(OH)D levels compared to those with poor compliance (25.8 ± 7.6 versus 20.4 ± 9.6 ng/ml, respectively; p = 0.038).

Conclusions: In conclusion, 12 months of CPAP therapy improved Vit D serum levels in OS patients, more so in compliant patients.

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CPAP治疗对阻塞性睡眠呼吸暂停和慢性阻塞性肺疾病重叠综合征患者维生素D状态的影响

目的：维生素D （Vit D）缺乏与阻塞性睡眠呼吸暂停（OSA）和慢性阻塞性肺疾病（COPD）以及它们的组合（称为重叠综合征（OS））有关。有证据表明，持续气道正压通气（CPAP）可导致OSA患者Vit D水平升高。然而，CPAP治疗对OS患者Vit D水平的影响尚未确定。本研究的目的是探讨一年CPAP治疗对OS患者Vit D水平的影响。方法：测量连续OS患者在基线和CPAP治疗一年后的血清Vit D水平。通过从CPAP设备检索的数据评估CPAP治疗的依从性。结果：测定了46例OS患者（男性43例）血清Vit D水平。在参与者中，27例CPAP治疗依从性好，19例依从性差。结果显示，CPAP治疗12个月后血清Vit D水平由21.3±8.4 ng/ml上升至23.8±8.7 ng/ml （p = 0.001）。此外，与依从性较差的患者相比，CPAP依从性良好的患者血清25(OH)D水平更高(分别为25.8±7.6 ng/ml和20.4±9.6 ng/ml；p = 0.038)。结论：CPAP治疗12个月后，OS患者血清Vit D水平得到改善，而依从性患者的Vit D水平改善更明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.