Changes in topological properties of brain structural covariance networks and alertness in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-05-14 Epub Date: 2025-05-07 DOI:10.1097/WNR.0000000000002164

Chuanyong Qu, Zexiang Chen, Shujun Su, Cuimi Luo, Ligen Fan, Yuting Sun, Jinou Zheng

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引用次数: 0

Abstract

This study investigated brain structural covariance network (SCN) topological changes and alertness in temporal lobe epilepsy (TLE) with and without focal to bilateral tonic-clonic seizures (FBTCS). Seventy-eight subjects, including 32 TLE patients with FBTCS (TLE-FBTCS), 46 TLE patients without FBTCS (TLE-FS), and 42 healthy controls (HCs), underwent the Attention Network Test to assess alertness and volumetric MRI scans. SCNs were constructed and analyzed using graph theory. Results showed that TLE-FS patients had lower total cerebral volume than HCs, and the lowest volume was observed in the TLE-FBTCS group. Compared to HCs and TLE-FBTCS patients, TLE-FS patients exhibited increased small-worldness, normalized clustering coefficient, global efficiency, and modularity, but decreased normalized characteristic shortest path length and assortativity. Specific brain regions, such as the hippocampus, thalamus, and superior temporal sulcus, showed changes in nodal clustering coefficients and efficiency in TLE-FS patients. Further analysis revealed decreased intrinsic/phasic alertness in TLE-FBTCS patients. Correlation analysis indicated that SCN topological properties were associated with alertness in TLE-FS patients but not in TLE-FBTCS patients. These findings suggest that TLE-FS and TLE-FBTCS patients show different changes in SCN integration and segregation, with TLE-FS alertness linked to SCN topological properties, providing insights into TLE's neuropathological mechanisms.

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颞叶癫痫伴或不伴局灶性至双侧强直-阵挛性发作时脑结构协方差网络拓扑特性和警觉性的变化。

本研究探讨了伴有或不伴有双侧强直-阵挛发作（FBTCS）的颞叶癫痫（TLE）的脑结构协方差网络（SCN）拓扑变化和警觉性。78名受试者，包括32名TLE合并FBTCS (TLE-FBTCS)， 46名TLE不合并FBTCS （TLE- fs）和42名健康对照（hc），进行了注意网络测试以评估警觉性和体积MRI扫描。利用图论构造和分析了scn。结果显示，TLE-FS患者的总脑容量低于hc，且以TLE-FBTCS组脑容量最低。与hc和TLE-FBTCS患者相比，TLE-FS患者表现出更高的小世界性、归一化聚类系数、全局效率和模块化，但归一化特征最短路径长度和分类性降低。在TLE-FS患者中，海马、丘脑、颞上沟等特定脑区显示出节点聚类系数和效率的变化。进一步分析显示，TLE-FBTCS患者的内在/相性警觉性降低。相关分析表明，SCN拓扑特性与le - fs患者的警觉性相关，而与le - fbtcs患者无关。这些研究结果表明，TLE- fs和TLE- fbtcs患者在SCN整合和分离方面表现出不同的变化，TLE- fs的警觉性与SCN的拓扑特性有关，为TLE的神经病理机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.