Neuroinflammation in diabetic peripheral neuropathy and therapeutic implications.

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Zhao Zhong Chong, Nizar Souayah
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引用次数: 0

Abstract

Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes mellitus, which is a common cause of disability in individuals with diabetes mellitus. Multiple mechanisms may be involved in the development of DPN. Neuroinflammation is a critical factor contributing to nerve damage during diabetes. Inflammation can induce the development of diabetes mellitus, and long-term hyperglycemia also causes increased oxidative stress and promotes the release of inflammatory cytokines. After reading through the literature, the association of inflammation with the induction of diabetes and DPN was discussed in the review. Inflammation induces nerve damage and nerve conduction impairment. The neuropathic pain in diabetes-induced DPN is also closely associated with the inflammatory response. Given the important roles of inflammation in diabetes-induced DPN, explicit elucidation of neuroinflammation during diabetes mellitus and DPN should hold the potential for developing novel therapeutic strategies for DPN. Experimental studies and limited clinical trials support the value of anti-inflammatory reagents in treating DPN, and the positive outcomes of these investigations warrant further clinical trials.

糖尿病周围神经病变的神经炎症及其治疗意义。
糖尿病周围神经病变(DPN)是糖尿病的严重并发症,是糖尿病患者致残的常见原因。DPN的发生可能涉及多种机制。神经炎症是糖尿病患者神经损伤的重要因素。炎症可诱发糖尿病的发展,长期高血糖还可引起氧化应激增加,促进炎症细胞因子的释放。在阅读文献后,本文讨论炎症与糖尿病和DPN诱导的关系。炎症引起神经损伤和神经传导障碍。糖尿病性DPN的神经性疼痛也与炎症反应密切相关。鉴于炎症在糖尿病诱导的DPN中的重要作用,明确阐明糖尿病和DPN期间的神经炎症应该具有开发新的DPN治疗策略的潜力。实验研究和有限的临床试验支持抗炎药物治疗DPN的价值,这些研究的积极结果为进一步的临床试验提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in the Neurosciences
Reviews in the Neurosciences 医学-神经科学
CiteScore
9.40
自引率
2.40%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal is meant to provide an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences. Contributions should contain a critical appraisal of specific areas and not simply a compilation of published articles.
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