Clinical repercussions of statin use during pregnancy: a review of the literature.

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Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.61622/rbgo/2025rbgo2

Joan Lins Serafim, Pedro Lucas Santos de Menezes Teles, Amanda Katharinne Souza Lima, Jéssica Dos Santos Coelho, Paloma Luna Maranhão Conrado, Valda Lúcia Moreira Luna, Pauliana Valéria Machado Galvão, George Alessandro Maranhão Conrado

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Abstract

Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.

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妊娠期间使用他汀类药物的临床影响：文献综述。

他汀类药物是治疗高脂血症最广泛使用的药物，但在怀孕期间禁用。本研究旨在通过互动式回顾来证明他汀类药物在孕妇中的临床效果。在五年内选出了15篇英文或葡萄牙文的原创文章。他汀类药物与胎儿畸形的发展没有关联，它们的使用可能有助于预防不利的心血管结果，具有减少氧化应激和血管生成功能障碍的潜力。然而，使用他汀类药物预防人类先兆子痫尚未得到适当的澄清，需要进一步的研究。在怀孕期间使用普伐他汀被认为比他汀类药物更安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

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