Frontal and Parietal Alpha Asymmetry as Biomarkers for Negative Symptoms in Schizophrenia.

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI:10.30773/pi.2024.0354

Yao-Cheng Wu, Chih-Chung Huang, Yi-Guang Wang, Chu-Ya Yang, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang

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引用次数: 0

Abstract

Objective: Negative symptoms in schizophrenia indicate a poor prognosis. However, the mechanisms underlying the development of negative symptoms remain unclear. This study investigated the relationship between negative symptoms in schizophrenia and frontal alpha asymmetry (FAA).

Methods: The study used a 32-channel electroencephalography to acquire alpha power in 4 target-paired sites in each patient. Regional alpha asymmetry was calculated based on the alpha power using EEGLAB Frontal Alpha Asymmetry Toolbox.

Results: Sixty schizophrenia patients with predominant negative symptoms (PNS), 72 stabilized schizophrenia (SS) patients, and 73 healthy control (HC) participants were enrolled in this study. No significant differences were observed in FAA between the PNS and SS groups, although both groups exhibited reduced P3-P4 alpha asymmetry compared to HCs. A positive correlation was found between F7-F8 alpha asymmetry and illness duration. Additionally, a predictive model based on P3-P4 alpha asymmetry scores was able to differentiate schizophrenia patients from HCs, achieving a sensitivity of 71.2% and a specificity of 72.6%.

Conclusion: This study highlighted that parietal alpha asymmetry could serve as a valuable diagnostic tool for schizophrenia.

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额叶和顶叶α不对称作为精神分裂症阴性症状的生物标志物

目的：精神分裂症的阴性症状预示预后不良。然而，发展阴性症状的机制尚不清楚。本研究探讨了精神分裂症阴性症状与额叶α不对称（FAA）的关系。方法：采用32通道脑电图在每位患者的4个靶配对部位获取α功率。利用EEGLAB额α不对称工具箱，根据α功率计算区域α不对称。结果：本研究共纳入60例显性阴性症状精神分裂症患者（PNS）、72例稳定型精神分裂症患者（SS）和73例健康对照（HC）。PNS组和SS组之间的FAA无显著差异，尽管与hc组相比，两组均表现出P3-P4 α不对称性降低。F7-F8 α不对称与病程呈正相关。此外，基于P3-P4 α不对称评分的预测模型能够区分精神分裂症患者和hc患者，灵敏度为71.2%，特异性为72.6%。结论：本研究强调顶叶α不对称可作为精神分裂症的一种有价值的诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.