Green Tea Ameliorates Depression-Like Behavior and Cognitive Impairment Induced by High-Fat Diet and Chronic Mild Stress.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Minghao Fan, Yudi Jiang, Chao Cai, Zhe Wang, Lu Chen, Shumin Hu, Xin Zhang, Hua Yin, Zhonghua Qian, Shuli Huang, Jiachen Yang
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引用次数: 0

Abstract

Depression often develops in young individuals and is linked to complications like cognitive impairment. Conventional antidepressants show limited efficacy in restoring cognitive function and may cause adverse effects. Green tea, a safe and health-promoting beverage, offers various health benefits. This study investigated the effects of long-term green tea consumption on stress-induced depression-like behavior and mild cognitive impairment in animal models. We established a rodent model of mild depression and studied the effects of green tea on depression-like behavior and cognitive impairment through comprehensive evaluation, including behavioral assessments, neurotransmitter quantification, gene and protein expression analysis, blood metabolite profiling, and gut microbiota characterization. Results demonstrated significant improvements in mood, long-term memory, and sterol and glycerophospholipid metabolism. Green tea repaired the intestinal barrier and upregulated genes vital for tight junctions and mucin production. It also enhanced gut microbiota composition, reducing the Firmicutes-to-Bacteroidetes ratio and promoting beneficial bacteria such as NK4A136, Muribaculum, and Gordonibacter. These microbiota changes improved liver lipid metabolism and alleviated depressive symptoms. Green tea effectively mitigates depression-like behavior and cognitive deficits by modulating the gut-liver-brain axis.

绿茶改善高脂肪饮食和慢性轻度应激引起的抑郁样行为和认知障碍。
抑郁症通常发生在年轻人身上,并与认知障碍等并发症有关。传统抗抑郁药在恢复认知功能方面疗效有限,并可能引起不良反应。绿茶是一种安全、有益健康的饮料,对健康有多种益处。本研究在动物模型中调查了长期饮用绿茶对应激诱导的抑郁样行为和轻度认知障碍的影响。我们建立轻度抑郁症啮齿动物模型,通过行为评估、神经递质定量、基因和蛋白质表达分析、血液代谢物谱和肠道菌群表征等综合评价,研究绿茶对抑郁样行为和认知功能障碍的影响。结果显示情绪、长期记忆、固醇和甘油磷脂代谢有显著改善。绿茶修复了肠道屏障,上调了对紧密连接和粘蛋白产生至关重要的基因。它还增强了肠道微生物群的组成,降低了厚壁菌与拟杆菌的比例,促进了有益细菌的生长,如NK4A136、Muribaculum和Gordonibacter。这些微生物群的改变改善了肝脏脂质代谢,减轻了抑郁症状。绿茶通过调节肠-肝-脑轴有效减轻抑郁样行为和认知缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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