Insights into body composition in pediatric craniopharyngioma patients after surgical treatment.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Therapeutic Advances in Endocrinology and Metabolism Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI:10.1177/20420188251336087

Hussein Zaitoon, Ori Eyal, Michal Yackobovitch-Gavan, Ravit Regev, Yael Issan, Jonathan Roth, Shlomi Constantini, Yael Lebenthal, Avivit Brener

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引用次数: 0

Abstract

Background: Craniopharyngioma, a benign suprasellar tumor, is typically treated surgically with radiotherapy when indicated. Due to its proximity to the pituitary-hypothalamic region, patients often experience endocrine deficiencies.

Objective: To explore the body composition components and their interaction with metabolic syndrome (MetS) components in pediatric craniopharyngioma patients after surgery.

Design: Longitudinal single-center real-life study of 33 pediatric patients who were diagnosed with craniopharyngioma for which they underwent surgery between 2012 and 2024.

Methods: Electronic medical reports were reviewed for clinical data, and a bioimpedance analysis (BIA) database was searched for body composition. Fifty-four BIA reports of 21 patients with craniopharyngioma were analyzed. The latest reported values were compared to those of 63 sex- and age-matched healthy controls. Changes in anthropometric measurements and indices of muscle and adiposity were assessed by linear mixed models.

Results: Patients with craniopharyngioma exhibited higher adiposity compared to controls, with significantly elevated total body fat percentage (FATP; p < 0.001), trunk-to-total body FATP ratio (p = 0.012), and lower muscle-to-fat ratio (MFR) z-scores (p < 0.001). The appendicular skeletal muscle mass (ASMM) z-scores were similar. A sex- and age-adjusted model revealed that the diagnosis of MetS components was positively associated with FATP [odds ratio = 1.13, confidence interval (1.04, 1.23), p = 0.006]. Patients with craniopharyngioma demonstrated an increase in ASMM z-score over time (β = 0.14, SE = 0.04, p = 0.002) together with a decline in sex- and age-adjusted FATP (β = -0.99, SE = 0.41, p = 0.018).

Conclusion: Despite struggling with obesity and hormonal deficiencies, survivors of craniopharyngioma showed favorable changes in body composition with appropriate medical interventions. Strategies to prevent metabolic complications and tailored hormone replacement therapies are essential for managing metabolic decline.

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小儿颅咽管瘤患者手术后身体成分的观察。

背景：颅咽管瘤是一种良性鞍上肿瘤，在有指征的情况下通常采用手术和放疗治疗。由于靠近垂体-下丘脑区，患者经常出现内分泌不足。目的：探讨小儿颅咽管瘤术后机体组成成分及其与代谢综合征（MetS）成分的相互作用。设计：纵向单中心现实研究，研究对象为33名确诊为颅咽管瘤并在2012年至2024年间接受手术的儿童患者。方法：查阅电子病历的临床资料，并在生物阻抗分析（BIA）数据库中检索人体成分。本文对21例颅咽管瘤患者的54例BIA报告进行分析。最新报告的数值与63名性别和年龄匹配的健康对照进行了比较。通过线性混合模型评估人体测量值和肌肉和脂肪指数的变化。结果：与对照组相比，颅咽管瘤患者表现出更高的脂肪，体脂率（FATP）显著升高；p p = 0.012)，较低的肌脂比（MFR） z分数（p z分数相似）。性别和年龄校正模型显示，MetS成分的诊断与FATP呈正相关[优势比= 1.13，置信区间（1.04,1.23），p = 0.006]。颅咽管瘤患者ASMM z-score随时间增加（β = 0.14, SE = 0.04, p = 0.002），性别和年龄调整后的FATP下降（β = -0.99, SE = 0.41, p = 0.018）。结论：颅咽管瘤患者尽管存在肥胖和激素缺乏的问题，但在适当的医疗干预下，其身体成分发生了良好的变化。预防代谢并发症的策略和量身定制的激素替代疗法对于控制代谢衰退至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

7.70

自引率

2.60%

发文量

审稿时长

8 weeks

期刊介绍： Therapeutic Advances in Endocrinology and Metabolism delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of endocrinology and metabolism.