Biomedical applications of organoids in genetic diseases.

Medical review (Berlin, Germany) Pub Date : 2024-12-24 eCollection Date: 2025-04-01 DOI:10.1515/mr-2024-0077
Wenhua Huang, Seogsong Jeong, Won Kim, Lei Chen
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引用次数: 0

Abstract

Organoid technology has significantly transformed biomedical research by providing exceptional prospects for modeling human tissues and disorders in a laboratory setting. It has significant potential for understanding the intricate relationship between genetic mutations, cellular phenotypes, and disease pathology, especially in the field of genetic diseases. The intersection of organoid technology and genetic research offers great promise for comprehending the pathophysiology of genetic diseases and creating innovative treatment approaches customized for specific patients. This review aimed to present a thorough analysis of the current advancements in organoid technology and its biomedical applications for genetic diseases. We examined techniques for modeling genetic disorders using organoid platforms, analyze the approaches for incorporating genetic disease organoids into clinical practice, and showcase current breakthroughs in preclinical application, individualized healthcare, and transplantation. Through the integration of knowledge from several disciplines, such as genetics, regenerative medicine, and biological engineering, our aim is to enhance our comprehension of the complex connection between genetic variations and organoid models in relation to human health and disease.

类器官在遗传疾病中的生物医学应用。
类器官技术通过在实验室环境中为人体组织和疾病建模提供了非凡的前景,极大地改变了生物医学研究。它对于理解基因突变、细胞表型和疾病病理之间的复杂关系具有重要的潜力,特别是在遗传疾病领域。类器官技术和基因研究的交叉为理解遗传疾病的病理生理学和为特定患者定制的创新治疗方法提供了巨大的希望。本文综述了类器官技术的最新进展及其在遗传疾病的生物医学应用。我们研究了利用类器官平台建模遗传疾病的技术,分析了将遗传疾病类器官纳入临床实践的方法,并展示了目前在临床前应用、个体化医疗和移植方面的突破。通过整合来自多个学科的知识,如遗传学、再生医学和生物工程,我们的目标是增强我们对遗传变异和类器官模型之间与人类健康和疾病相关的复杂联系的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.30
自引率
0.00%
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