mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI:10.1016/j.it.2025.03.004

Byron Brook, Morgan Goetz, Valerie Duval, Romain Micol, David J Dowling

引用次数: 0

Abstract

The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.

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mRNA疫苗：基于mirna的可控生物分布和定向佐剂。

可电离mRNA-脂质纳米颗粒（mRNA- lnp）核酸载体的开发促进了2019冠状病毒（COVID-19） mRNA疫苗BNT162b2和mRNA-1273的临床翻译。在这里，我们讨论了合理改进mRNA疫苗的见解，重点是LNP修饰mRNA-LNP生物分布控制，基于mirna的编码转录物生物分布控制以及精确调节策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.