PERMA-based psychological intervention in glioma rehabilitation: An RCT on affective distress, treatment adherence, and neuro-oncological outcomes.

IF 1.3 4区医学 Q4 PSYCHIATRY

International Journal of Psychiatry in Medicine Pub Date : 2025-05-09 DOI:10.1177/00912174251341978

Yang Huang, Zijuan Jiang, Yujuan Qi, Juan Deng, Dan Wang, Qian Zhang, Haiyan Qiu

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引用次数: 0

Abstract

ObjectivePostoperative glioma patients often experience negative emotions, affecting their treatment adherence and prognosis. The PERMA intervention (focusing on Positive emotions, Engagement, Relationship, Meaning, and Accomplishment) seeks to enhance psychological well-being and quality of life (QoL). This study examines its effects on negative emotions, treatment adherence, and prognosis in postoperative glioma patients.MethodsA total of 124 postoperative glioma patients from January 2022 to February 2024 were randomly assigned to an intervention group (n = 62) or a control group (n = 62). The control group received routine postoperative care, while the intervention group received additional PERMA psychological intervention for 1 month. Assessments included anxiety symptoms (SAS), depressive symptoms (SDS), treatment adherence, complications, and QoL. Prognosis was analyzed using Kaplan-Meier (KM) survival curves.ResultsBaseline characteristics were comparable between groups (P > 0.05). After intervention, both groups showed significant improvements in SAS and SDS scores (P < 0.05), furthermore, post-intervention SAS and SDS scores in the intervention group were significantly lower than those in the control group (P < 0.0001). Treatment adherence was significantly higher, and complication rates were lower in the intervention group compared to control group (P < 0.05). QoL was improved in both groups (P < 0.05), notably, post-intervention, the intervention group scored significantly higher than control group across all QoL domains (P < 0.0001). KM analysis revealed a significant association between the PERMA-based intervention and better prognosis (P < 0.05).ConclusionPERMA-based psychological intervention effectively reduces anxiety and depression, enhances treatment adherence, lowers complication risks, and improves QoL in postoperative glioma patients.

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神经胶质瘤康复中基于permaar的心理干预：一项关于情感困扰、治疗依从性和神经肿瘤预后的随机对照试验。

目的胶质瘤术后患者常出现负面情绪，影响其治疗依从性和预后。PERMA干预（关注积极情绪、参与、关系、意义和成就）旨在提高心理健康和生活质量（QoL）。本研究探讨其对胶质瘤术后患者负面情绪、治疗依从性和预后的影响。方法选取2022年1月~ 2024年2月收治的124例胶质瘤术后患者，随机分为干预组（n = 62）和对照组（n = 62）。对照组术后给予常规护理，干预组术后给予PERMA心理干预1个月。评估包括焦虑症状（SAS）、抑郁症状（SDS）、治疗依从性、并发症和生活质量。采用Kaplan-Meier （KM）生存曲线分析预后。结果两组间基线特征具有可比性（P < 0.05）。干预后，两组患者SAS、SDS评分均有显著改善（P < 0.05），且干预组干预后SAS、SDS评分显著低于对照组（P < 0.0001）。干预组患者治疗依从性明显高于对照组，并发症发生率明显低于对照组（P < 0.05）。两组患者的生活质量均有改善（P < 0.05），干预后，干预组患者生活质量各领域评分均显著高于对照组（P < 0.0001）。KM分析显示，基于pama的干预与较好的预后有显著相关性（P < 0.05）。结论基于permaar的心理干预可有效减轻胶质瘤术后患者的焦虑和抑郁情绪，提高治疗依从性，降低并发症发生风险，改善患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Medicine 医学-精神病学

CiteScore

3.00

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...