Health-related quality of life and lifestyle in long-term survivors of colorectal cancer and a matched non-cancer reference group.

IF 2.5 3区医学 Q2 ONCOLOGY

Clinical & Translational Oncology Pub Date : 2025-10-01 Epub Date: 2025-04-29 DOI:10.1007/s12094-025-03930-0

Magdalena Esteva, Sebastià March, María Martín-Rabadan, Elena Torres-Solera, Joana Ripoll

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引用次数: 0

Abstract

Objective: To compare the long-term health status of a group of survivors of colorectal cancer (CRC) with a reference group of individuals who did not have cancer. We determined the physical, mental, and general health-related quality of life (HRQoL); overall morbidities and CRC-specific morbidities related to the delayed effects of treatment; and maintenance of a healthy lifestyle in these two groups.

Methods: This descriptive cross-sectional study was conducted from 2016 to 2019 in the Balearic Islands (Spain). CRC patients who were diagnosed from 2011 to 2012 and survived at least 5 years were randomly selected from the Majorca and Eivissa-Formentera cancer registries. The reference group consisted of individuals matched for gender and age who had no history of cancer.

Results: We examined 201 CRC survivors and 199 matched individuals without cancer. The global analysis showed that the two groups had similar scores in the physical and mental components of the Short Form 12 (SF-12) HRQoL scale and in general health status. The CRC survivors had significantly higher prevalence of general comorbidity and CRC-specific comorbidity. Multivariate analyses and calculation of odds ratios (ORs) showed that the groups had similar physical HRQoL (Model 1, OR: 1.01, 95% CI: 0.99-1.03), mental HRQoL (Model 2, OR: 0.99, 95% CI: 0.66-1.01), and general HRQoL (Model 3, OR: 1.67, 95% CI: 0.39-1.13). However, the long-term CRC survivors had significantly greater ORs for an increased overall comorbidity index, number of CRC-specific comorbidity, and obesity in all three models (P < 0.05).

Conclusions: The CRC survivors and individuals without cancer had similar HRQoL, suggesting that CRC survivors do not need additional services that aim to improve HRQoL. Nonetheless, health care providers should be pro-active when caring for CRC survivors, because they are more likely to present with certain comorbidity and less likely to follow a healthy lifestyle.

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结直肠癌长期幸存者和匹配的非癌症参照组的健康相关生活质量和生活方式

目的：比较一组结直肠癌（CRC）幸存者与对照组未患癌症个体的长期健康状况。我们测定了身体、心理和一般健康相关生活质量（HRQoL）；总体发病率和与治疗延迟效应相关的crc特异性发病率；保持健康的生活方式。方法：本描述性横断面研究于2016年至2019年在巴利阿里群岛（西班牙）进行。从马略卡和埃维萨-福门特拉癌症登记处随机选择2011年至2012年诊断并存活至少5年的结直肠癌患者。参照组由性别和年龄相匹配的无癌症病史的个体组成。结果：我们检查了201名结直肠癌幸存者和199名匹配的无癌个体。整体分析显示，两组在短表12 (SF-12) HRQoL量表的生理和心理部分以及总体健康状况方面得分相似。结直肠癌幸存者一般合并症和结直肠癌特异性合并症的发生率明显较高。多因素分析和优势比（OR）计算显示，两组的身体HRQoL（模型1，OR: 1.01, 95% CI: 0.99-1.03）、精神HRQoL（模型2，OR: 0.99, 95% CI: 0.66-1.01）和一般HRQoL（模型3，OR: 1.67, 95% CI: 0.39-1.13）相似。然而，在所有三种模型中，CRC长期幸存者的总体合并症指数、CRC特异性合并症数量和肥胖的发生率均显著增加(P)。结论：CRC幸存者和无癌症个体的HRQoL相似，表明CRC幸存者不需要旨在改善HRQoL的额外服务。尽管如此，卫生保健提供者在照顾结直肠癌幸存者时应该积极主动，因为他们更有可能出现某些合并症，并且不太可能遵循健康的生活方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.