Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the volumetric contraction of post-extraction sockets: a double-blinded randomized controlled clinical trial.

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Quintessence international Pub Date : 2025-04-29 DOI:10.3290/j.qi.b6184324

Leda M L Araujo, Walterson M Prado, Elton G Zenobio, Leonardo P Faverani, Joao Gabriel de Souza, Gustavo Vicentis Oliveira Fernandes, Jamil A Shibli

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the effect of recombinant human bone morphogenic protein type-2 (rhBMP-2) on the alveolar ridge in the post-extraction socket in humans.

Materials and methods: 20 subjects with 25 teeth of the maxilla were included (11 sockets in the control [blood clot] and 14 in the test group [rhBMP2]). The teeth were minimally and traumatically extracted. The cone-beam computed tomography (CBCT) images were obtained 2 (T0) and 120 (T1) days after extraction. The Buccal bone wall height (V Height, mm), palatal bone wall height (P Height, mm), and alveolar area (mm2) were compared between both groups as well as the volumetric contraction through overlapped images (T1-T0) using mimics software. The data was compared using the Mann-Whitney test (p<0.05).

Results: The intragroup evaluation showed a significant buccal and palatal crest height resorption in the control group (p<0.05). In the intergroup assessment, the test group showed superior to the control group in maintaining the average alveolar ridge area since the control group showed an area loss of approximately 39% between T0 and T1, whereas this reduction was approximately 15% in the test group (p<0.05).

Conclusion: It is possible to conclude that using rhBMP-2 after tooth extraction resulted in better socket preservation, maintaining bone availability in the alveolar ridge 2.5 times greater than that of the control group.

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重组人骨形态发生蛋白-2 （rhBMP-2）对拔牙后牙槽容积收缩的影响：一项双盲随机对照临床试验。

目的：研究重组人骨形态发生蛋白2型（rhBMP-2）对人拔牙后牙槽槽牙槽嵴的影响。材料与方法：纳入20例受试者，共25颗上颌骨牙齿（对照组[血凝块]牙槽11个，试验组[rhBMP2]牙槽14个）。这些牙齿是用微创和创伤性方法拔出来的。提取后2 （T0）天和120 （T1）天分别获得锥束计算机断层扫描（CBCT）图像。比较两组口腔骨壁高度（V height, mm）、腭骨壁高度（P height, mm）和牙槽面积（mm2），并利用mimics软件通过重叠图像（T1-T0）比较体积收缩。结果：组内评价结果显示，对照组患者颊、腭嵴高度吸收显著(p)。结论：拔牙后使用rhBMP-2可以更好地保存牙槽骨，维持牙槽嵴骨可用性是对照组的2.5倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quintessence international 医学-牙科与口腔外科

CiteScore

3.30

自引率

5.30%

发文量

审稿时长

1 months

期刊介绍： QI has a new contemporary design but continues its time-honored tradition of serving the needs of the general practitioner with clinically relevant articles that are scientifically based. Dr Eli Eliav and his editorial board are dedicated to practitioners worldwide through the presentation of high-level research, useful clinical procedures, and educational short case reports and clinical notes. Rigorous but timely manuscript review is the first order of business in their quest to publish a high-quality selection of articles in the multiple specialties and disciplines that encompass dentistry.