Electroconvulsive therapy ameliorates treatment-resistant depression in patient with Lewy body dementia.

IF 0.5 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2025-08-01 Epub Date: 2025-04-12 DOI:10.1080/13554794.2025.2490785

Yavuz Sultan Selim Akgul, Murat Gultekin, Saliha Demirel Ozsoy

引用次数: 0

Abstract

Lewy body dementia (LBD), the second most common degenerative dementia after Alzheimer's disease, is frequently associated with neuropsychiatric symptoms such as depression, anxiety, and apathy. These symptoms may precede cognitive decline, often resulting in misdiagnosis and inappropriate treatment. Electroconvulsive therapy (ECT) has emerged as a promising option for treatment-resistant depression in LBD. This report describes a 68-year-old female patient with LBD who received multiple ECT sessions for persistent severe depression and suicidal ideation. ECT led to marked symptom improvement across several hospitalizations. This case underscores the diagnostic and therapeutic challenges of neuropsychiatric symptoms in LBD and highlights ECT as a potential alternative when pharmacotherapy is inadequate. Early identification of LBD in patients with late-onset depression is essential to guide individualized treatment strategies.

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电休克疗法改善路易体痴呆患者的难治性抑郁症。

路易体痴呆（LBD）是仅次于阿尔茨海默病的第二常见的退行性痴呆，常伴有神经精神症状，如抑郁、焦虑和冷漠。这些症状可能先于认知能力下降，常常导致误诊和不适当的治疗。电痉挛疗法（ECT）已成为治疗LBD难治性抑郁症的一种有希望的选择。本报告描述了一位68岁的LBD女性患者，她因持续严重抑郁症和自杀意念接受了多次ECT治疗。ECT在几次住院治疗中显著改善了症状。该病例强调了LBD中神经精神症状的诊断和治疗挑战，并强调了当药物治疗不足时，ECT是一种潜在的替代方法。早期识别迟发性抑郁症患者的LBD对于指导个体化治疗策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.