An in-depth exploration of the catecholamine and dyslipidemia relationship in pheochromocytoma and paraganglioma patients: a large Chinese cohort study.
Wenqian Zhang, Yue Zhou, Yunying Cui, Jie Yu, Tianyi Li, Kai Feng, Weidong Ren, Anli Tong, Yuxiu Li
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引用次数: 0
Abstract
Objective: The aim is to investigate the relationship between catecholamine levels and dyslipidemia in pheochromocytoma and paraganglioma (PPGL) patients.
Methods: Clinical data from 500 PPGL patients were retrospectively analyzed, including clinical demographics, genetic mutations, tumor size, preoperative catecholamine levels, and lipid profiles. Comparison of lipid levels before and after surgery were also conducted.
Results: A total of 500 patients were included: 238 males (47.6%) and 262 females (52.4%), with an average age at diagnosis of 46.5 ± 15.4 years. The prevalence of dyslipidemia among PPGL patients was 59.2%. In different catecholamine secretion types, norepinephrine (NE) secreting type group had significantly higher total cholesterol levels (4.82 [4.21, 5.38] vs. 4.43 [3.78, 4.92] mmol/L, p < 0.0167) compared to the non-secreting type group. However, there were no significant differences in triglycerides, high-density lipoprotein, and low-density lipoprotein among different secretion types. This study showed the first detailed analysis of the distribution of elevated total cholesterol in different age groups and BMI categories. Patients with overweight had the highest rate of elevated total cholesterol (48.5%). Additionally, within different age brackets, individuals aged 51-60 years displayed the highest rate of abnormal total cholesterol levels. Comparison of preoperative and postoperative biochemical outcomes in 69 patients with PPGLs showed that surgical resection effectively reduced catecholamine levels and improved total cholesterol levels.
Conclusions: The incidence of dyslipidemia is high among patients with PPGL, and there exists strong link between lipid metabolism and catecholamine secretion, thus highlighting the importance of closely monitoring lipid levels in patients with PPGL.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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