The Interplay Between the Sleep Slow Oscillation and Cerebrospinal Fluid: New Vistas for Insomnia Research.

Abstract

Insomnia disorder affects about 10% of the global population, representing a major health concern. Despite the availability of evidence-based treatments, the neurobiological mechanisms underpinning this disorder remain poorly understood. Recently, the investigation of the less than 1 Hz oscillations (commonly termed slow oscillations), a hallmark of slow wave sleep, has gained increased interest in research on insomnia. In this context, an intriguing perspective arises from the association between slow oscillations and metabolic waste clearance, an impaired process in individuals suffering from insomnia disorder. Indeed, the exploration of the relationships between cerebrospinal fluid dynamics and glymphatic system functions, which relate to brain metabolic clearance, and sleep slow oscillations may represent a promising avenue for future research in this field. This narrative review examines current knowledge about the intricate interplay among these mechanisms and their implications for insomnia disorder. Particular attention is given to the role of sleep slow oscillations in the clearance of metabolic waste during sleep, their coupling with cerebrospinal fluid oscillations, and the regulatory mechanisms underlying glymphatic function. The review emphasises the relevance of investigating sleep slow oscillations-related mechanisms in insomnia, intending to provide novel insights into the neurophysiological underpinnings of the disorder and contribute to more accurate diagnostic approaches. Furthermore, a deeper understanding of these mechanisms could pave the way for the development of innovative or adjunctive therapeutic strategies targeting sleep slow oscillations-related alterations in insomnia disorder.