Cervicovaginal microbiota in Chlamydia trachomatis and other preventable sexually transmitted infections of public health importance: a systematic umbrella review.

IF 1.5 4区 医学 Q4 MICROBIOLOGY
New Microbiologica Pub Date : 2025-05-01
Marisa Di Pietro, Simone Filardo, Rosa Sessa
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引用次数: 0

Abstract

A dysbiotic cervicovaginal microbiota, characterized by the overgrowth of anaerobic bacteria, leads to bacterial vaginosis, known to increase the risk of acquiring sexually transmitted infections. The present umbrella review aims to summarize evidence from systematic reviews and meta-analyses on how cervicovaginal microbiota changes in relation to preventable sexually transmitted infections of public health importance, namely Chlamydia trachomatis, Neisseria gonorrhoeae, and human papillomavirus. The databases PubMed, Scopus, and Web of Science were searched with the following strategy: ((chlamydia trachomatis) OR (treponema pallidum) OR (HPV) OR (neisseria gonorrhoeae)) AND (((microbio*) OR (metagen*)) AND (genital)); a total of 12 studies were included. Overall, this umbrella review highlighted that a highly diverse cervicovaginal microbiota has been associated with C. trachomatis infection and can be considered a risk factor in pre-cancerous lesions/cervical cancer related to high-risk HPV infections, whereas the role of cervicovaginal microbiota in N. gonorrhoeae infection is still unclear. In conclusion, specific microbial profiles associated with a high risk for each sexually transmitted pathogen have not yet been identified, and, in the future, more advanced multi-omics approaches will be helpful to clearly describe the etiopathogenetic relationships between resident microorganisms and genital conditions.

沙眼衣原体和其他具有公共卫生重要性的可预防性传播感染中的宫颈阴道微生物群:一项系统的保护伞综述。
以厌氧菌过度生长为特征的宫颈阴道微生物群失调,会导致细菌性阴道病,已知会增加获得性传播感染的风险。本综述旨在总结来自系统综述和荟萃分析的证据,这些证据表明宫颈阴道微生物群的变化与具有公共卫生重要性的可预防性传播感染(即沙眼衣原体、淋病奈瑟菌和人乳头瘤病毒)有关。检索PubMed、Scopus和Web of Science数据库的策略如下:(沙眼衣原体)或(梅毒螺旋体)或(HPV)或(淋病奈瑟菌))和((微生物学*)或(metagen*))和(生殖器);共纳入12项研究。总的来说,这一综述强调了高度多样化的宫颈阴道微生物群与沙眼衣原体感染有关,并且可以被认为是与高危HPV感染相关的癌前病变/宫颈癌的危险因素,而宫颈阴道微生物群在淋病奈瑟菌感染中的作用尚不清楚。总之,与每种性传播病原体的高风险相关的特定微生物谱尚未确定,在未来,更先进的多组学方法将有助于清楚地描述常驻微生物与生殖器疾病之间的发病关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
New Microbiologica
New Microbiologica 生物-微生物学
CiteScore
2.20
自引率
5.60%
发文量
40
审稿时长
6-12 weeks
期刊介绍: The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.
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