Low Levels of Serum Ghrelin and Nesfatin-1 Are Associated With Anxiety Disorders in Children.

IF 0.8 Q4 PSYCHIATRY
Ayhan Bilgiç, Merve Cura, İbrahim Kılınç, Ömer Faruk Akça
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Abstract

Objectives: Because appetite-regulating hormones are implicated in neuronal survival, growth, and differentiation, they have been suggested to play a role in anxiety disorders. To date, few studies have focused on the association between these hormones and anxiety disorders in children. This study investigated the potential differences in leptin, ghrelin, and nesfatin-1 serum levels in drug-naïve children with anxiety disorders, including social anxiety disorder, separation anxiety disorder, and generalized anxiety disorder, and in healthy controls.

Methods: This study included 45 children (14 boys and 31 girls) with anxiety disorders and 35 healthy controls (13 boys and 22 girls) aged 8-18 years. The severity of anxiety disorders and additional symptoms were evaluated using the Revised Child Anxiety and Depression Scales-Child Version. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate leptin, ghrelin, and nesfatin-1 serum levels.

Results: Leptin levels were significantly higher in children with anxiety disorders than in the control group, and ghrelin and nesfatin-1 levels were significantly lower in children with anxiety disorders than in the control group for girls and for the entire sample. However, only low nesfatin-1 levels were significantly associated with anxiety disorders in boys. In the entire sample, potential confounders such as age, sex, body mass index, and the severity of depressive symptoms were controlled for, and the results were the same for ghrelin and nesfatin-1 levels. However, the difference in leptin levels between groups was not significant.

Conclusion: These findings suggest that dysregulation of ghrelin and nesfatin-1 concentrations may be related to the etiopathogenesis of childhood anxiety disorders.

低水平的血清Ghrelin和Nesfatin-1与儿童焦虑症有关
目的:由于食欲调节激素与神经元的存活、生长和分化有关,它们被认为在焦虑症中发挥作用。迄今为止,很少有研究关注这些激素与儿童焦虑症之间的关系。本研究调查了drug-naïve焦虑障碍儿童(包括社交焦虑障碍、分离焦虑障碍和广泛性焦虑障碍)和健康对照组中瘦素、饥饿素和nesfatin-1血清水平的潜在差异。方法:本研究纳入45名8-18岁的焦虑障碍儿童(男孩14名,女孩31名)和35名健康对照(男孩13名,女孩22名)。使用修订儿童焦虑和抑郁量表-儿童版评估焦虑障碍和其他症状的严重程度。采用酶联免疫吸附试验(ELISA)检测瘦素、胃饥饿素和nesfatin-1血清水平。结果:焦虑障碍儿童的瘦素水平明显高于对照组,女孩和整个样本中焦虑障碍儿童的胃饥饿素和nesfatin-1水平明显低于对照组。然而,只有低巢脂素-1水平与男孩的焦虑症有显著关联。在整个样本中,潜在的混杂因素,如年龄、性别、体重指数和抑郁症状的严重程度都得到了控制,胃饥饿素和巢脂素-1水平的结果是相同的。然而,两组之间瘦素水平的差异并不显著。结论:这些发现提示ghrelin和nesfatin-1浓度失调可能与儿童焦虑症的发病机制有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
5.00%
发文量
20
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