Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999-2004 and Mendelian Randomization.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Pain Research Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S516748

Chunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang

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引用次数: 0

Abstract

Purpose: The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers.

Methods: Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.

Results: 20% of total participants reported migraines. A higher ALM/BMI ratio was inversely associated with migraine after full adjustment (OR = 0.243; 95% CI: 0.122-0.487, p < 0.001). Vigorous activity reduced migraine susceptibility by 24% (OR = 0.760; 95% CI: 0.663-0.872, p < 0.001). CRP, WBC and neutrophils mediated 2.0% (p = 0.024), 3.1% (p = 0.011), and 2.8% (p = 0.019) of the ALM/BMI-migraine association, respectively. The inverse-variance weighted approach (IVW) in MR analysis indicated that higher basal metabolic rate (BMR) reduced migraine risk (OR = 0.996, 95% CI: 0.992-0.998, p = 0.004) and headache risk (OR = 0.998, 95% CI: 0.997-1.000, p = 0.018). Fat-free mass also exhibited protective effects on migraines (OR = 0.997, 95% CI: 0.994-1.000, p = 0.045).

Conclusion: Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.

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炎症因子介导肌肉质量和偏头痛的关联：NHANES 1999-2004和孟德尔随机化。

目的：脂肪-肌肉分布与偏头痛的关系尚不清楚。本研究探讨了肌肉质量与偏头痛患病率之间的关系，并评估了全身炎症生物标志物的潜在中介作用。方法：采用横断面设计，对1999-2004年全国健康与营养检查调查（NHANES） 10400名参与者的数据进行分析。通过加权logistic回归和亚组分析评估经身体质量指数（ALM/BMI）归一化的阑尾瘦质量与偏头痛患病率之间的关系。通过中介分析，研究炎症标志物（包括c反应蛋白（CRP）、白细胞计数（WBC）和中性粒细胞）在ALM/BMI与偏头痛患病率之间的关系中的潜在中介作用。采用全基因组关联研究（GWAS）数据，通过双样本孟德尔随机化（MR）研究遗传因果关系。结果：20%的参与者报告有偏头痛。完全调整后，较高的ALM/BMI比值与偏头痛呈负相关(OR = 0.243；95% CI: 0.122 ~ 0.487, p < 0.001)。剧烈运动使偏头痛易感性降低24% (OR = 0.760；95% CI: 0.663-0.872, p < 0.001)。CRP、WBC和中性粒细胞分别介导ALM/ bmi -偏头痛相关性的2.0% （p = 0.024）、3.1% （p = 0.011）和2.8% （p = 0.019）。MR分析的反方差加权方法（IVW）表明，较高的基础代谢率（BMR）降低偏头痛风险（OR = 0.996, 95% CI: 0.992-0.998, p = 0.004）和头痛风险（OR = 0.998, 95% CI: 0.997-1.000, p = 0.018）。无脂块对偏头痛也有保护作用（OR = 0.997, 95% CI: 0.994-1.000, p = 0.045）。结论：肌肉质量的增加与偏头痛风险的降低有关，部分是通过减轻全身炎症介导的。这些发现为我们提供了一种预防偏头痛的健康管理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pain Research CLINICAL NEUROLOGY-

CiteScore

4.50

自引率

3.70%

发文量

411

审稿时长

16 weeks

期刊介绍： Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.