[A Case of Radical Nephrectomy that Achieved Complete Remission after Combination Therapy with Pembrolizumab and Lenvatinib for Metastatic Renal Cell Carcinoma].

Q4 Medicine
Hitoshi Yokozeki, Takaaki Takuma, Kazuki Kokura, Shoko Uketa, Tomohiro Fukui, Yuichi Uemura, Jun Watanabe
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引用次数: 0

Abstract

An 81-year-old woman to our hospital complaining of backpain and was diagnosed with a left renal tumor with lung and iliac metastasis. A renal tumor biopsy confirmed clear cell renal cell carcinoma. The patient began combination therapy with pembrolizumab and lenvatinib but experienced fatigue and edema after 1 month. Suspecting cardiac dysfunction induced by Lenvatinib, Lenvatinib was discontinued and treatment with pembrolizumab alone was continued. Three months after treatment initiation, the lung and iliac metastases had resolved, allowing for laparoscopic nephrectomy. Five months post-surgery, no new metastases were detected.

[1例根治性肾切除术经派姆单抗和Lenvatinib联合治疗转移性肾细胞癌获得完全缓解]。
一名81岁妇女来我院主诉背部疼痛,诊断为左肾肿瘤伴肺及髂转移。肾肿瘤活检证实透明细胞肾细胞癌。患者开始使用派姆单抗和lenvatinib联合治疗,但1个月后出现疲劳和水肿。怀疑Lenvatinib引起心功能障碍,停用Lenvatinib,继续单独使用派姆单抗治疗。治疗开始三个月后,肺和髂转移已经消退,允许腹腔镜肾切除术。术后5个月未发现新的转移灶。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Urologica Japonica
Acta Urologica Japonica Medicine-Medicine (all)
CiteScore
0.20
自引率
0.00%
发文量
74
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