Growth differentiation factor 15: a promising biomarker in oral cancer.

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the Korean Association of Oral and Maxillofacial Surgeons Pub Date : 2025-04-30 DOI:10.5125/jkaoms.2025.51.2.123

Hyun Jun Oh, Jong-Ho Lee, Soung Min Kim

引用次数: 0

Abstract

Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.

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生长分化因子15：一个有前景的口腔癌生物标志物。

生长分化因子15 （GDF-15）是转化生长因子-β超家族中的一种细胞因子，与多种恶性肿瘤有关，与口腔鳞状细胞癌（OSCC）有关。GDF-15水平升高与不良预后、肿瘤进展和化疗耐药相关，该蛋白已被确定为OSCC的潜在诊断和预后生物标志物。基于GDF-15表达的个性化治疗策略可以改善治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Korean Association of Oral and Maxillofacial Surgeons DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.00

自引率

10.00%

发文量

期刊介绍： Journal of the Korean Association of Oral and Maxillofacial Surgeons (J Korean Assoc Oral Maxillofac Surg) is the official journal of the Korean Association of Oral and Maxillofacial Surgeons. This bimonthly journal offers high-quality original articles, case series study, case reports, collective or current reviews, technical notes, brief communications or correspondences, and others related to regenerative medicine, dentoalveolar surgery, dental implant surgery, head and neck cancer, aesthetic facial surgery/orthognathic surgery, facial injuries, temporomandibular joint disorders, orofacial disease, and oral pathology. J Korean Assoc Oral Maxillofac Surg is of interest to oral and maxillofacial surgeons and dental practitioners as well as others who are interested in these fields.