[Retinal ischemia as an early marker of renal failure in non-proliferative retinopathy].

Arturo Muñoz-Cornejo, Gloria Paulina Trujillo-Sánchez, Luis Miguel López-Montero, Martha Alicia Hernández-González
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引用次数: 0

Abstract

Background: Type 2 diabetes mellitus (T2DM) presents complications such as diabetic retinopathy (DR) and nephropathy, both related to microvascular damage. DR is the leading cause of preventable blindness in T2DM. Retinal ischemia, detectable by fluorescein angiography (FA), is an early indicator, and its timely detection is crucial. Endothelial dysfunction affects vessels in organs such as the retina and kidneys. Microalbuminuria (MA) is an early sign of diabetic nephropathy (DN). Early detection, along with adequate metabolic control, can delay progression to end-stage renal disease.

Objective: To investigate the relationship between retinal ischemia, detected by FA, and MA in patients with T2DM and non-proliferative DR at the No. 1 Specialty Hospital of Bajío.

Material and methods: Cross-sectional study, with ethical approval. Diabetic patients without previous renal disease or proliferative DR were included. The sample of 66 patients was evaluated by FA and MA analysis (>30 mg/24 h). Chi-square and Student's t-tests were applied.

Results: Patients with retinal ischemia were older (62.73 ± 8.93 vs. 57.50 ± 14.14 years; p = 0.05) and had a higher prevalence of MA (45% vs. 0%; p = 0.01). No significant differences were found in gender, DR severity, HbA1c, or creatinine levels.

Conclusions: Retinal ischemia is associated with a higher prevalence of microalbuminuria in T2DM patients, supporting the study hypothesis.

[视网膜缺血作为非增殖性视网膜病变肾功能衰竭的早期标志]。
背景:2型糖尿病(T2DM)的并发症包括糖尿病视网膜病变(DR)和肾病,两者都与微血管损伤有关。DR是2型糖尿病患者可预防失明的主要原因。视网膜缺血,荧光素血管造影(FA)检测,是一个早期指标,它的及时检测是至关重要的。内皮功能障碍影响视网膜和肾脏等器官的血管。微量白蛋白尿(MA)是糖尿病肾病(DN)的早期征兆。早期发现,以及适当的代谢控制,可以延缓进展到终末期肾脏疾病。目的:探讨Bajío第一专科医院T2DM合并非增殖性DR患者视网膜缺血(FA检测)与MA的关系。材料和方法:经伦理批准的横断面研究。既往无肾脏疾病或增殖性DR的糖尿病患者也包括在内。对66例患者进行FA和MA分析(>30 mg/24 h)。采用卡方检验和学生t检验。结果:视网膜缺血患者年龄较大(62.73±8.93∶57.50±14.14岁;p = 0.05),且MA患病率较高(45%比0%;P = 0.01)。在性别、DR严重程度、HbA1c或肌酐水平方面没有发现显著差异。结论:视网膜缺血与T2DM患者中较高的微量白蛋白尿患病率相关,支持研究假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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