Association between glycated hemoglobin and cognitive impairment in older adults with coronary heart disease: a multicenter prospective cohort Study.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Geriatric Cardiology Pub Date : 2025-03-28 DOI:10.26599/1671-5411.2025.03.010

Wen Zheng, Qin-Jie Xin, Xiao-Xia Wang, Sheng Li, Xiao Wang, Shao-Ping Nie

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引用次数: 0

Abstract

Background: The relationship between glycated hemoglobin (HbA1c) and cognitive impairment in older adults with coronary heart disease (CHD) remains unclear.

Methods: The present study used a prospective cohort study design and included 3244 participants aged ≥ 65 years in Beijing, China. The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess cognitive function. Serum HbA1c was detected at admission. All patients were divided into high HbA1c group (≥ 6.5 mmol/L) and low HbA1c group (< 6.5 mmol/L) based on their HbA1c levels. Logistic regression analyses were used to evaluate the association between HbA1c and cognitive impairment.

Results: In this study of 3244 participants, 1201 (37.0%) patients were in high HbA1c group and 2045 (63.0%) patients were in a state of cognitive impairment. Logistic regression analyses demonstrated that HbA1c was an independent risk factor for cognitive impairment regardless of whether the HbA1c was a continuous or categorical variable (OR = 1.27, 95% CI: 1.15-1.40, P < 0.001; OR = 1.79, 95% CI: 1.41-2.26, P ≤ 0.001, respectively). The restricted cubic spline curve exhibited that the relationship between the HbA1c and cognitive impairment was linear (p for non-linear = 0.323, P < 0.001).

Conclusion: Elevated levels of HbA1c were associated with an increased risk of cognitive impairment in older patients with CHD. These insights could be used to improve the accuracy and sensitivity of cognitive screening in these patient populations.

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老年冠心病患者糖化血红蛋白与认知障碍的关系：一项多中心前瞻性队列研究

背景：老年冠心病（CHD）患者糖化血红蛋白（HbA1c）与认知功能障碍的关系尚不清楚。方法：本研究采用前瞻性队列研究设计，纳入3244名年龄≥65岁的中国北京参与者。采用简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）评估认知功能。入院时检测血清HbA1c。根据患者的HbA1c水平分为高HbA1c组（≥6.5 mmol/L）和低HbA1c组（< 6.5 mmol/L）。采用Logistic回归分析评估HbA1c与认知功能障碍之间的关系。结果：本研究3244例受试者中，高HbA1c组1201例（37.0%），认知功能障碍状态2045例（63.0%）。Logistic回归分析显示，无论HbA1c是连续变量还是分类变量，HbA1c都是认知障碍的独立危险因素(or = 1.27, 95% CI: 1.15-1.40, P < 0.001；OR = 1.79, 95% CI: 1.41 ~ 2.26, P≤0.001)。限制三次样条曲线显示HbA1c与认知功能障碍呈线性关系（p = 0.323, p < 0.001）。结论：HbA1c水平升高与老年冠心病患者认知功能障碍风险增加相关。这些见解可用于提高这些患者群体认知筛查的准确性和敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY

CiteScore

3.30

自引率

4.00%

发文量

1161

期刊介绍： JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.