Multidisciplinary expert consensus on diagnosis and treatment of multiple lung cancers.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-04-11 DOI:10.1016/j.medj.2025.100643

Kezhong Chen, Anwen Liu, Changli Wang, Chengping Hu, Chun Chen, Fan Yang, Haiquan Chen, Hongbing Shen, Hongtao Zhang, Hongxu Liu, Jianping Xiong, Jie Wang, Li Zhang, Lin Xu, Lvhua Wang, Mingfang Zhao, Qiang Li, Qibin Song, Qinghua Zhou, Qun Wang, Shenglin Ma, Shidong Xu, Shuanghu Yuan, Shugeng Gao, Shun Lu, Weimin Li, Weimin Mao, Xiaoqing Liu, Xiaorong Dong, Xuening Yang, Yilong Wu, Ying Cheng, Yong Song, Yunchao Huang, Zhenfa Zhang, Zhiwei Chen, Zhiyong Ma, Christoph C Zielinski, Yu Shyr, Jun Wang

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引用次数: 0

Abstract

The rising incidence of multiple lung cancers (MLCs), encompassing multiple primary lung cancers (MPLCs) and intrapulmonary metastasis (IPM), poses two significant clinical challenges. First, distinguishing between MPLC and IPM remains difficult due to insufficiently accurate criteria and ambiguous integration of genetic testing. Second, standardized therapeutic protocols are still lacking. To address these issues, the Lung Cancer Expert Committee of China Anti-Cancer Association (CACA) assembled a multidisciplinary expert panel spanning thoracic surgery, pulmonary medicine, oncology, radiology, and pathology. Following a comprehensive literature review ending on October 23, 2024, the panel engaged in iterative discussions and conducted two rounds of expert voting, culminating in 25 evidence-based recommendations across five key domains: epidemiology, pre-treatment evaluation, definitive diagnostics, surgical treatment, and non-surgical treatment. This consensus provides clinicians with practical guidance to enhance diagnostic precision and therapeutic decision-making in MLC management while highlighting unmet needs to inform future guideline development.

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多学科专家对多发性肺癌诊断和治疗的共识。

包括多发性原发肺癌（MPLCs）和肺内转移（IPM）在内的多发性肺癌（MLCs）的发病率不断上升，给临床带来了两大挑战。首先，区分MPLC和IPM仍然很困难，因为标准不够准确，基因检测的整合也不明确。第二，标准化的治疗方案仍然缺乏。为了解决这些问题，中国抗癌协会肺癌专家委员会（CACA）召集了一个多学科专家小组，涵盖胸外科、肺部医学、肿瘤学、放射学和病理学。在全面的文献综述于2024年10月23日结束后，专家组进行了反复讨论并进行了两轮专家投票，最终在五个关键领域提出了25项循证建议：流行病学、治疗前评估、明确诊断、手术治疗和非手术治疗。这一共识为临床医生提供了实用的指导，以提高MLC管理的诊断精度和治疗决策，同时强调了未满足的需求，为未来指南的制定提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.