Apelinergic System in the Left Ventricle Adverse Remodeling After Myocardial Infarction: A Preliminary Study.

IF 2.6 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Health and Risk Management Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.2147/VHRM.S507783

Rafał Wyderka, Bogusława Ołpińska, Dorota Diakowska, Anna Leśków, Łukasz Osuch, Michał Borger, Barbara Brzezińska, Maria Łoboz-Rudnicka, Joanna Jaroch

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引用次数: 0

Abstract

Background: Despite a growing evidence from the animal models of the cardioprotective function of the apelinergic system in the setting of myocardial infarction, little is known on the role of apelinergic system in the development of post- infarction adverse left ventricle remodeling in humans.

Methods: The study group consisted of 49 patients with first-time ST-segment elevation myocardial infarction of anterior wall treated invasively. Echocardiography was performed on index hospitalization and on one-year check-up, with categorizing the study population into group with adverse LV remodeling defined as an increase of LV end diastolic volume by >20% (n = 12) and the group without adverse remodeling (n = 29). ELA, AP-17, AP-13 and APJ receptor levels were measured on one-year follow-up.

Results: Patients with adverse LV remodeling presented significantly higher plasma level of apelin-13 (85.63 [75.43-96.13] vs 65.43 [57.35-69.35], p = 0.001) and apelin-17 (69.36 [42.61-77.04] vs 30.04 [25.97-41.95], p = 0.004). In a univariable logistic regression analysis, higher LVEDV and LVEDV1, higher LVESV and LVESVi, lower LVEF, higher WMSI score, higher SYNTAX score, higher levels of hs-CRP during index hospitalization and higher levels of AP-13 and AP-17 on the one-year check-up were associated with adverse LV remodeling. In multivariable logistic regression analysis, only AP-17 level was independently associated with adverse LV remodeling (p = 0.050).

Conclusion: Apelinergic system may be involved in the development of post- infarction adverse left ventricle remodeling.

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心肌梗死后左心室不良重构中的乙酰胆碱能系统：初步研究。

背景：尽管越来越多的动物模型证据表明，在心肌梗死的情况下，乙酰胆碱能系统具有心脏保护功能，但对乙酰胆碱能系统在人类梗死后不良左心室重构中的作用知之甚少。方法：研究组49例经有创治疗的首次st段抬高型前壁心肌梗死患者。在指数住院和一年体检时进行超声心动图检查，将研究人群分为左室不良重构组（定义为左室舒张末期容积增加bbb20 %）和无不良重构组（n = 29）。随访1年，测量ELA、AP-17、AP-13和APJ受体水平。结果：不良左室重构患者血浆apelin-13水平（85.63 [75.43-96.13]vs 65.43 [57.35-69.35], p = 0.001）和apelin-17水平（69.36 [42.61-77.04]vs 30.04 [25.97-41.95], p = 0.004）显著升高。在单变量logistic回归分析中，较高的LVEDV和LVEDV1、较高的LVESV和LVESVi、较低的LVEF、较高的WMSI评分、较高的SYNTAX评分、住院期间较高的hs-CRP水平以及一年体检时较高的AP-13和AP-17水平与不良左室重构相关。在多变量logistic回归分析中，只有AP-17水平与左室不良重构独立相关（p = 0.050）。结论：乙酰胆碱能系统可能参与了梗死后不良左心室重构的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vascular Health and Risk Management PERIPHERAL VASCULAR DISEASE-

CiteScore

4.20

自引率

3.40%

发文量

109

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.