Infracyanine Green-Based Photodynamic Therapy for Immune-Mediated Keratitis in Horses.

IF 1.7 4区农林科学 Q2 VETERINARY SCIENCES

Veterinary ophthalmology Pub Date : 2025-05-05 DOI:10.1111/vop.70027

Kimberly P Lam, Deborah A Keys, Richard J McMullen

{"title":"Infracyanine Green-Based Photodynamic Therapy for Immune-Mediated Keratitis in Horses.","authors":"Kimberly P Lam, Deborah A Keys, Richard J McMullen","doi":"10.1111/vop.70027","DOIUrl":null,"url":null,"abstract":"Objective: To describe infracyanine green-based photodynamic therapy (InfraCG-PDT) and evaluate outcomes in horses with immune-mediated keratitis (IMMK).Animals studied: Medical records from 2014 to 2020 from the Equine Clinic Munich-Riem, Germany, and Auburn University Equine Ophthalmology Service identified horses diagnosed with IMMK following ophthalmic examination that had undergone InfraCG-PDT.Procedures: Multiple intrastromal injections of EmunDo (InfraCG, A.R.C. Laser, Nuernberg, Germany) within an affected quadrant or the entire cornea were treated with diffuse diode laser energy (FOX A.R.C., Laser, Nuernberg, Germany, 500 mW at 30s cycles) irradiation between 75 J (J, quadrant) and 300 J (entire cornea).Results: Fifty-one eyes (22 OS, 19 OD, 10 OU) from 47 horses were included (22 geldings, 20 mares, and 5 stallions) from 15 breeds aged between 4 and 29 years (median 14 years). Individual quadrants (28/51 eyes, 54.9%) or the entire cornea (23/51 eyes, 45.1%) were treated. Complications were defined as immediate: intrastromal fracture (4/51 eyes, 7.8%), intracameral InfraCG (7/51 eyes, 13.7%), and an epithelial blister (1/51 eyes, 1.9%) or short term: prolonged dye retention (51/51 eyes, 100%, with gradual reduction over a 12-week period) and superficial corneal ulceration (15/51 eyes, 29.4%). Globe threatening ulcers (3/51 eyes, 5.9%) resolved without significant complications. IMMK remained inactive (controlled or managed with improvement in ocular lesions) in 31/40 horses (77.5%) during follow-up (mean 223.0 ± 269.3 days; range 14-1095 days), 4/40 horses (10.0%) required additional treatment, and 5/40 horses (12.5%) were lost to follow-up.Conclusions: InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.","PeriodicalId":23836,"journal":{"name":"Veterinary ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary ophthalmology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vop.70027","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To describe infracyanine green-based photodynamic therapy (InfraCG-PDT) and evaluate outcomes in horses with immune-mediated keratitis (IMMK).

Animals studied: Medical records from 2014 to 2020 from the Equine Clinic Munich-Riem, Germany, and Auburn University Equine Ophthalmology Service identified horses diagnosed with IMMK following ophthalmic examination that had undergone InfraCG-PDT.

Procedures: Multiple intrastromal injections of EmunDo (InfraCG, A.R.C. Laser, Nuernberg, Germany) within an affected quadrant or the entire cornea were treated with diffuse diode laser energy (FOX A.R.C., Laser, Nuernberg, Germany, 500 mW at 30s cycles) irradiation between 75 J (J, quadrant) and 300 J (entire cornea).

Results: Fifty-one eyes (22 OS, 19 OD, 10 OU) from 47 horses were included (22 geldings, 20 mares, and 5 stallions) from 15 breeds aged between 4 and 29 years (median 14 years). Individual quadrants (28/51 eyes, 54.9%) or the entire cornea (23/51 eyes, 45.1%) were treated. Complications were defined as immediate: intrastromal fracture (4/51 eyes, 7.8%), intracameral InfraCG (7/51 eyes, 13.7%), and an epithelial blister (1/51 eyes, 1.9%) or short term: prolonged dye retention (51/51 eyes, 100%, with gradual reduction over a 12-week period) and superficial corneal ulceration (15/51 eyes, 29.4%). Globe threatening ulcers (3/51 eyes, 5.9%) resolved without significant complications. IMMK remained inactive (controlled or managed with improvement in ocular lesions) in 31/40 horses (77.5%) during follow-up (mean 223.0 ± 269.3 days; range 14-1095 days), 4/40 horses (10.0%) required additional treatment, and 5/40 horses (12.5%) were lost to follow-up.

Conclusions: InfraCG-PDT may be an effective treatment for horses with IMMK. Further studies are needed to optimize this treatment modality.

查看原文本刊更多论文

马免疫介导性角膜炎的紫花青绿光动力治疗。

目的：描述以紫花青绿为基础的光动力疗法（InfraCG-PDT）并评估免疫介导性角膜炎（IMMK）马的疗效。研究动物：2014年至2020年德国慕尼黑-里姆马诊所和奥本大学马眼科服务中心的医疗记录确定了在眼科检查后诊断为IMMK的马，这些马接受了InfraCG-PDT。操作步骤：在受影响的象限或整个角膜内多次注射EmunDo (InfraCG， A.R.C. Laser, Nuernberg, Germany)，用漫射二极管激光能量（FOX A.R.C. Laser, Nuernberg, Germany, 500 mW， 30个周期）照射75 J （J，象限）至300 J（整个角膜）。结果：共对15个品种47匹马（公马22匹，母马20匹，种马5匹）进行了51只眼（正常眼22只，正常眼19只，正常眼10只）的检查，年龄在4 ~ 29岁之间（中位14岁）。单个象限（28/51眼，54.9%）或整个角膜（23/51眼，45.1%）进行了治疗。并发症定义为即时：眼间骨折（4/51眼，7.8%），眼间内InfraCG（7/51眼，13.7%）和上皮水疱（1/51眼，1.9%）或短期：长期染料潴留（51/51眼，100%，在12周内逐渐减少）和浅表角膜溃疡（15/51眼，29.4%）。威胁眼球的溃疡（3/51眼，5.9%）消失，无明显并发症。在随访期间（平均223.0±269.3天），31/40匹马（77.5%）的IMMK保持无活性（眼部病变得到控制或改善）；范围14-1095天)，4/40匹马（10.0%）需要额外治疗，5/40匹马（12.5%）失去随访。结论：InfraCG-PDT可能是治疗马imk的有效方法。需要进一步的研究来优化这种治疗方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Veterinary ophthalmology 农林科学-兽医学

CiteScore

2.70

自引率

37.50%

发文量

审稿时长

12-24 weeks

期刊介绍： Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of: Clinical and investigational veterinary and comparative ophthalmology; Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species; Experimental models of both animal and human ocular disease in veterinary species; Anatomic studies of the animal eye; Physiological studies of the animal eye; Pharmacological studies of the animal eye.