Increased risk of postoperative pancreatic fistula in patients with chronic steroid usage undergoing pancreatectomy.

IF 1.6 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-10-01 Epub Date: 2025-04-28 DOI:10.1007/s00595-025-03028-8

Wataru Fujii, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Shinichiro Hasegawa, Daisaku Yamada, Hirofumi Akita, Takehiro Noda, Tetsuhisa Kitamura, Yuichiro Doki, Hidetoshi Eguchi

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引用次数: 0

Abstract

Purpose: Chronic steroid use may increase the risk of postoperative complications; however, its impact on postoperative outcomes after pancreatectomy has not been fully investigated. This study investigated the impact of chronic steroid use on surgical outcomes, particularly postoperative pancreatic fistulas (POPF).

Methods: A retrospective analysis of 656 patients who underwent pancreatectomy between 2010 and 2021 was conducted. Patients who had been using steroids for ≥ 1 month at the time of surgery were classified into the steroid group. Postoperative outcomes were compared between the steroid-treated and non-steroid-treated groups.

Results: Of the 656 patients, 17 (2.6%) were in the steroid group, which exhibited a significantly higher POPF rate than the non-steroid group (70.6% vs. 26.3%, p = 0.0002). A multivariate analysis identified chronic steroid use as an independent risk factor for POPF (odds ratio 4.718, 95% confidence interval 1.510-14.742; p = 0.0051). The results were confirmed using a propensity score matching analysis.

Conclusion: The risk of POPF was significantly increased after pancreatectomy in patients with chronic steroid use compared to those without chronic steroid use, and chronic steroid use was an independent factor significantly associated with POPF.

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慢性类固醇患者行胰腺切除术后胰瘘的风险增加。

目的：长期使用类固醇可能增加术后并发症的风险；然而，其对胰腺切除术后预后的影响尚未得到充分研究。本研究调查了慢性类固醇使用对手术结果的影响，特别是术后胰瘘（POPF）。方法：回顾性分析2010年至2021年间656例行胰腺切除术的患者。手术时使用类固醇≥1个月的患者分为类固醇组。比较类固醇治疗组和非类固醇治疗组的术后结果。结果：656例患者中，类固醇组17例（2.6%），其POPF率显著高于非类固醇组（70.6% vs. 26.3%, p = 0.0002）。一项多变量分析确定慢性类固醇使用是POPF的独立危险因素(优势比4.718,95%可信区间1.510-14.742；P = 0.0051)。使用倾向评分匹配分析证实了结果。结论：与未使用类固醇的患者相比，慢性类固醇使用的患者在胰腺切除术后发生POPF的风险明显增加，并且慢性类固醇使用是与POPF显著相关的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.