Comparative Analysis of Biological Aging and Inflammatory Profiles in Adult Spinal Deformity Patients Between Japan and the United States: A Correlative Study.
Mitsuru Yagi, Naobumi Hosogane, Christopher P Ames, Michael P Kelly, Justin S Smith, Christopher I Shaffrey, Frank J Schwab, Virginie Lafage, Shay Bess
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Abstract
Study design: Retrospective matched cohort study.
Objective: Understanding biological aging in adult spinal deformity (ASD) across different populations offers insights into its impact on aging and potential interventions.
Summary of background data: ASD significantly impacts physiological health and may accelerate biological aging. Understanding biological aging in ASDs across different populations offers insights into ASD's impact on aging and potential interventions.
Materials and methods: ASDs and norms from Japan (JP) and the U.S. (US) were included. The US norm consisted of 8,751 adults from NHNES 2017-20; the JP norm comprised 10,205 adults from health check-ups between 2020-23. Age- and gender-matched norm cohorts of 6,584 pairs (JP vs. US) were established (age: 55±13 vs. 55±14 y; female: 49 vs. 50%). ASD were age-, race- and gender-matched to norm individuals in JP (159 pairs) and the US (132 pairs). Additionally, 81 pairs of ASDs from JP and US were selected for cross-country comparisons.
Results: The JP was biologically younger than the US (PhenoAge: mean difference [MD] -6.5±0.3 y; P<0.01). When comparing JP and US Asians, the JP remained biologically younger (MD: -3.1±0.7 y; P<0.01), suggesting lifestyle differences. JP ASDs were biologically older than their norms (MD: 4.2±1.7 y; P=0.02), indicating accelerated aging. However, no significant difference was observed between ASDs and the norms in the US. No significant difference in PhenoAge was found between JP and US ASDs (57.9±18.4 vs. 59.6±17.6 y; P=0.56). ASDs in both countries exhibited higher systemic inflammation, with US ASDs showing particularly elevated CRP levels (US ASD vs. norm: 2.8±8.5 vs. 0.4±0.8 mg/dL; P<0.01; JP: 0.5±1.3 vs. 0.2±0.4 mg/dL; P<0.01).
Conclusions: JP are biologically younger than their US counterparts, potentially due to lifestyle factors. JP ASDs exhibit accelerated biological aging compared to the norm cohort, highlighting the impact of ASD on aging. Elevated systemic inflammation in ASDs underscores the importance of managing inflammatory processes.
研究设计：回顾性匹配队列研究。目的：了解不同人群中成人脊柱畸形（ASD）的生物学老化，有助于了解其对衰老的影响和潜在的干预措施。背景资料总结：ASD显著影响生理健康，并可能加速生物衰老。了解不同人群中自闭症谱系障碍的生物学老化，有助于了解自闭症谱系障碍对衰老的影响和潜在的干预措施。材料和方法：包括日本（JP）和美国（US）的asd和规范。美国标准包括来自NHNES 2017-20的8,751名成年人；JP标准包括2020-23年间进行健康检查的10205名成年人。建立了6584对年龄和性别匹配的规范队列（日本vs美国）(年龄：55±13 vs 55±14；女性：49% vs. 50%)。ASD在年龄、种族和性别上与日本（159对）和美国（132对）的正常个体相匹配。此外，还选择了81对来自日本和美国的自闭症谱系障碍进行跨国比较。结果：JP在生物学上比美国年轻(表型年龄：平均差[MD] -6.5±0.3 y；结论：日本人在生理上比美国人年轻，可能是由于生活方式的因素。与正常队列相比，JP ASD表现出加速的生物衰老，突出了ASD对衰老的影响。asd全身性炎症升高强调了控制炎症过程的重要性。
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Recognized internationally as the leading journal in its field, Spine is an international, peer-reviewed, bi-weekly periodical that considers for publication original articles in the field of Spine. It is the leading subspecialty journal for the treatment of spinal disorders. Only original papers are considered for publication with the understanding that they are contributed solely to Spine. The Journal does not publish articles reporting material that has been reported at length elsewhere.
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