The predictive value of neutrophil-lymphocyte ratio combined with the Global Registry of Acute Coronary Events score for inhospital adverse cardiovascular events in patients with acute ST-elevation myocardial infarction.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Journal of Research in Medical Sciences Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI:10.4103/jrms.jrms_485_22
Caoyang Fang, Zhenfei Chen, Jing Zhang, Xiaoqin Jin, Mengsi Yang
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引用次数: 0

Abstract

Background: The research explores the predictive efficacy of the neutrophil-to-lymphocyte ratio (NLR) in conjunction with the Global Registry of Acute Coronary Events (GRACEs) score for inhospital major adverse cardiovascular events (MACEs) among acute ST-segment elevation myocardial infarction (STEMI) subjects with primary percutaneous coronary intervention (PCI) history.

Materials and methods: Patients were categorized into MACE (n = 58) and non-MACE cohorts (n = 184) based on MACE occurrence events during hospitalization. The predictive value of the NLR, GRACE score, and their combination for inhospital MACE events in STEMI subjects was assessed by the receiver operating characteristic curve (ROC).

Results: NLR (8.99 [5.06, 12.01] vs. 5.15 [3.13, 7.66]) and GRACE scores (159.62 ± 43.39 vs. 116.96 ± 28.15) within MACE group notably surpassed the non-MACE group (P < 0.05). ROC curve analysis demonstrated that the area under the curve (AUC) for NLR in forecasting inhospital MACE events was 0. 72 (95% confidence interval [CI]: 0.645-0.795), with 0.655 sensitivity and 0.723 specificity, and optimal cutoff value as 7.01. The AUC for the GRACE score was 0.791 (95% CI: 0.717-0.865), with 0.862 sensitivity and 0.598 specificity, and the optimal cutoff value was 121.5. The combined AUC of NLR and GRACE score was 0.814 (95% CI: 0.745-0.884), with 0.707 sensitivity and 0.837 specificity.

Conclusion: Both NLR and GRACE score independently predict inhospital MACE events in STEMI patients post-PCI. Integration of the NLR and GRACE score enhances accuracy in forecasting inhospital MACE event occurrences.

中性粒细胞-淋巴细胞比值结合急性冠状动脉事件全球登记评分对急性st段抬高型心肌梗死患者住院不良心血管事件的预测价值
背景:本研究探讨了中性粒细胞与淋巴细胞比值(NLR)结合急性冠状动脉事件全球登记(GRACEs)评分对具有原发性经皮冠状动脉介入治疗(PCI)史的急性st段抬高型心肌梗死(STEMI)患者住院主要不良心血管事件(mace)的预测作用。材料与方法:根据住院期间MACE发生事件将患者分为MACE组(n = 58)和非MACE组(n = 184)。采用受试者工作特征曲线(ROC)评估NLR、GRACE评分及其组合对STEMI患者住院MACE事件的预测价值。结果:MACE组NLR(8.99[5.06, 12.01]比5.15[3.13,7.66])和GRACE评分(159.62±43.39比116.96±28.15)明显优于非MACE组(P < 0.05)。ROC曲线分析显示,NLR预测院内MACE事件的曲线下面积(AUC)为0。72(95%可信区间[CI]: 0.645-0.795),敏感性0.655,特异性0.723,最佳截断值为7.01。GRACE评分的AUC为0.791 (95% CI: 0.717-0.865),敏感性为0.862,特异性为0.598,最佳截断值为121.5。NLR与GRACE评分的联合AUC为0.814 (95% CI: 0.745 ~ 0.884),敏感性0.707,特异性0.837。结论:NLR和GRACE评分均可独立预测STEMI患者pci术后的院内MACE事件。整合NLR和GRACE评分可提高预测院内MACE事件发生的准确性。
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来源期刊
Journal of Research in Medical Sciences
Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
6.20%
发文量
75
审稿时长
3-6 weeks
期刊介绍: Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.
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