MXene and prostate cancer: is there promising news?

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI:10.1080/17435889.2025.2487412
Mohammad Reza Fattahi, Mostafa Baghlani, Scott E Eggener, Mansoureh Dehghani, Mohammad-Mehdi Khani, Abdolmohammad Kajbafzadeh
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Abstract

Prostate cancer is the most prevalent cancer among men worldwide, and there have been many advances in its diagnosis and treatment. However, critical obstacles remain, including overdiagnosis, high rates of negative biopsies, management of side effects, and the timely detection of relapse. Despite these improvements, surgery and radiotherapy are still associated with a significant risk of short- or long-term side effects. MXenes are a novel class of two-dimensional nanomaterials manufactured through electrochemical procedures that accept a wide-termination of hydrophilic molecules as surface modifications. The importance of MXene has increased owing to many aspects, such as its high-gain synthesis potential, chemical flexibility, and high biocompatibility. Hence, MXene is a convenient nanomaterial that can be modified and synthesized in different models, suggesting its ability to improve screening, diagnosis, and theranostic applications, such as thermal therapy. These features have been used to detect potential urothelial tumor markers as well as the direction and accumulation of cancer medications in the target tissue.

MXene和前列腺癌:有好消息吗?
前列腺癌是世界上最常见的男性癌症,在诊断和治疗方面取得了许多进展。然而,关键的障碍仍然存在,包括过度诊断、高阴性活检率、副作用管理和及时发现复发。尽管有了这些改善,手术和放疗仍然存在短期或长期副作用的重大风险。MXenes是一种新型的二维纳米材料,通过电化学过程制造,可以接受广泛的亲水分子作为表面修饰。由于其高增益的合成潜力、化学柔韧性和高生物相容性,MXene的重要性日益增加。因此,MXene是一种方便的纳米材料,可以在不同的模型中进行修饰和合成,这表明它能够改善筛查,诊断和治疗应用,如热疗法。这些特征已被用于检测潜在的尿路上皮肿瘤标志物,以及肿瘤药物在靶组织中的方向和积累。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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