Cardiac Dysfunction and Subclinical Atherosclerosis in Post-COVID-19 Patients.

IF 4.2 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiac Failure Review Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI:10.15420/cfr.2024.21
Angela Cozma, Violeta Briciu, Adela Viviana Sitar-Tăut, Daniel Leucuţa, Nicolae-Dan Sporiş, Andrada-Luciana Lazar, Toma-Vlad Mălinescu, Andreea-Maria Ganea, Călin Vasile Vlad, Mihaela Lupşe, Adriana Fodor, Andreea Terec, Ramona Suharoschi, Madalina Indre, Olga Hilda Orăşan
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引用次数: 0

Abstract

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is still a burden for healthcare systems worldwide. Now, the focus is not only on acute infections, but also on the long-term effects of COVID-19. The present study aimed to evaluate the impact of SARS-CoV-2 infection on the cardiovascular system, and determine the evolution of these changes over 6 months in patients with mild and moderate COVID-19.

Methods: The prospective observational study included 103 patients with mild and moderate COVID-19. The patients underwent an echocardiography and a measurement of the arterial stiffness parameters at baseline and 6 months from the initial assessment.

Results: The diastolic dysfunction (the left atrium volume) was statistically significant at baseline and at the 6-month follow-up in men with moderate COVID-19. The ejection fraction presented significant differences globally in mild versus moderate COVID-19 (p=0.043) that disappeared at 6-month follow-up. Global longitudinal strain alterations were also found in both mild and moderate COVID-19 cases. Regarding the aortic pulse wave velocity, the SARS-CoV-2 infection did not influence the arterial stiffness. Ventricular arterial coupling was significantly altered in moderate COVID-19 at the 6-month evaluation (p=0.0218). Male patients presented a lower tricuspid annular plane systolic excursion at baseline. Right ventricular systolic dysfunction was more frequent among men. Systolic pulmonary arterial pressure increased significantly only in men with moderate disease. Additionally, statistically significant changes at baseline and at 6 months were found regarding the intima-media thickness.

Conclusion: This study shows the cardiovascular long-term sequelae associated with COVID-19 in mild and moderate cases, and emphasises the appropriate investigations for their diagnosis and follow-up.

covid -19后患者心功能障碍与亚临床动脉粥样硬化
背景:严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)大流行仍然是全球卫生保健系统的负担。现在,重点不仅放在急性感染上,还放在COVID-19的长期影响上。本研究旨在评估SARS-CoV-2感染对心血管系统的影响,并确定轻、中度COVID-19患者在6个月内这些变化的演变。方法:前瞻性观察研究纳入103例轻中度COVID-19患者。患者在基线和初始评估后6个月接受超声心动图检查和动脉硬度参数测量。结果:中度COVID-19男性患者的舒张功能障碍(左心房容积)在基线和6个月随访时均有统计学意义。在轻度和中度COVID-19患者中,射血分数在全球范围内存在显著差异(p=0.043),在6个月的随访中消失。在轻中度COVID-19病例中也发现了全球纵向应变变化。在主动脉脉波速度方面,SARS-CoV-2感染对动脉硬度无影响。在6个月评估时,中度COVID-19患者的心室动脉耦合发生显著改变(p=0.0218)。男性患者在基线时表现为下三尖瓣环状平面收缩偏移。右心室收缩功能障碍在男性中更为常见。收缩压仅在患有中度疾病的男性中显著升高。此外,在基线和6个月时,发现内膜-中膜厚度有统计学意义的变化。结论:本研究显示了轻、中度病例与COVID-19相关的心血管长期后遗症,并强调了对其诊断和随访的适当调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
31
审稿时长
9 weeks
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