Kateryna Priadko, Felice Crocetto, Carmine Sciorio, Biagio Barone, Antonio Tufano, Luigi Napolitano, Savio D Pandolfo, Marco Romano, Lorenzo Romano
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引用次数: 0
Abstract
Background: Chronic liver diseases are associated with impaired sex hormone metabolism and downregulation of the hypothalamic-pituitary-gonadal axis. Clinically, this may manifest as a variety of sexual disorders, such as erectile dysfunction, lower urinary tract symptoms, and even infertility. Psychological and mental disturbances associated with liver diseases aggravate sexual dysfunction even further. The existing gap in theoretical knowledge of pathophysiological mechanisms linking the above mentioned conditions explains the lack of attention to sexual health in this cohort of patients in a clinical setting.
Objectives: To review and analyze the latest available literature evidence on the possible pathophysiologial links and clinical associations of chronic liver diseases with sexual dysfunction in both sexes.
Methods: The PubMed database was searched using terms "chronic liver disease", "liver cirrhosis", "viral hepatitis B", "viral hepatitis C", "non-alcoholic fatty liver disease", "metabolic dysfunction-associated steatotic liver disease", "alcoholic liver disease" and "erectile dysfunction," "hypogonadism," "infertility". Articles published in the time period between January 1995 and December 2024 were reviewed.
Results: A total of 100 articles were reviewed, represented by preclinical original research articles, human observational and clinical studies, as well as meta-analyses relating chronic liver diseases to the development and progression of erectile dysfunction, hypogonadism, and infertility in males and females.
Conclusions: Chronic liver diseases are associated with a vast variety of sexual dysfunctions in both sexes. Erectile dysfunction is most commonly present and is possibly reversible following antiviral therapy or liver transplantation. The strengths of the association found between liver diseases and sexual dysfunction dictate the need to develop new diagnostic and therapeutic approaches in such patients.
期刊介绍：
Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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