Superficial white matter hyperintensities are associated with mild tissue alterations in vascular aging

IF 2.3 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2025-06-01 DOI:10.1016/j.neurol.2025.03.014

A. Aghetti , V. Bouteloup , J. Lebenberg , M. Chupin , E. Gourieux , J.-F. Mangin , G. Chêne , C. Dufouil , E. Jouvent , behalf of the Memento Study Group

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引用次数: 0

Abstract

In the elderly, white matter hyperintensities (WMH) are usually rated as periventricular or deep. However, recent data suggest that superficial WMH may be associated with distinct mechanisms and may be associated with milder underlying tissue alterations. We developed and validated a new grading scale to differentiate superficial WMH from other WMH (either periventricular or deep). We evaluated individuals with high loads of WMH from MEMENTO, a multicenter memory-clinic study, to evaluate the links between superficial WMH and 1) MRI markers of cerebral small vessel disease (number of lacunes and microbleeds and normalized brain volume); 2) cognitive outcomes including global evaluation with Mini Mental State Examination (MMSE). Our analytical sample included 208 participants. Participants with higher grades of superficial WMH had larger normalized brain volumes (82.1 ± 1.3% vs 81.0 ± 1.1%, P < 0.001) and were more frequently women (85.0% vs 51.4%, P = 0.01). In total contrast but as expected, participants with higher grades of other WMH were older (79.8 ± 8.1 vs 75.5 ± 6.2 years, P < 0.001), had more often lacunes (41.7% vs 7.1%, P < 0.001) and performed worse at the MMSE (26.8 ± 2.0 vs 28.1 ± 1.7, P = 0.01). Our results support the hypothesis that superficial WMH are distinct from other WMH and probably correspond to mild tissue alterations.

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在血管老化中，浅表白质高信号与轻度组织改变有关。

在老年人中，白质高信号（WMH）通常被认为是心室周围或深部。然而，最近的数据表明，浅表WMH可能与不同的机制有关，并可能与较轻的潜在组织改变有关。我们开发并验证了一种新的分级量表来区分浅表性脑积水和其他脑积水（心室周围或深部）。我们评估了来自MEMENTO（一项多中心记忆临床研究）的高负荷WMH个体，以评估浅表WMH与1)脑小血管疾病的MRI标志物（凹窝和微出血的数量以及正常脑容量）之间的联系；2)认知结果包括Mini Mental State Examination （MMSE）的整体评价。我们的分析样本包括208名参与者。浅表性WMH分级越高的参与者，其标准化脑容量越大(82.1±1.3% vs 81.0±1.1%，P

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.