Experimental study on reconstructing mandibular defects using porous titanium in goats.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care Pub Date : 2025-05-01 Epub Date: 2024-12-22 DOI:10.1177/09287329241301653

Zhiping Jiang, Zhuoyu Xia, Xuanyi Dai, Liangbing Wang

引用次数: 0

Abstract

This research aimed to explore the effects of varying porosities and pore sizes in porous titanium on osteointegration following mandibular defect reconstruction in goats. Porous titanium products were fabricated using spark plasma sintering technology combined with powder metallurgy techniques. Based on experimental requirements, standard porous titanium samples were categorized into three groups: Group A with 50%-70% porosity and 100-300 μm pore size; Group B with 70%-85% porosity and 300-500 μm pore size; and Group C with no porosity. These samples were implanted into the mandibular defects of goats, which were euthanized three months after implantation for analysis. The assessment of osteointegration involved general observations, X-ray, micro-CT, biomechanical testing, and histological examinations. Results indicated that Group B's porous titanium exhibited superior osteointegration, making it the most suitable material for enhancing cellular and tissue growth.

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多孔钛修复山羊下颌骨缺损的实验研究。

本研究旨在探讨不同孔隙率和孔径的多孔钛对山羊下颌骨缺损重建后骨整合的影响。采用火花等离子烧结技术和粉末冶金技术相结合的方法制备了多孔钛制品。根据实验要求，将标准多孔钛样品分为三组：A组孔隙率为50% ~ 70%，孔径为100 ~ 300 μm；B组孔隙率70% ~ 85%，孔径300 ~ 500 μm；C组无孔隙度。这些样品被植入山羊下颌骨缺损，在植入三个月后安乐死进行分析。骨整合的评估包括一般观察、x线、显微ct、生物力学测试和组织学检查。结果表明，B组多孔钛具有良好的骨整合性，是促进细胞和组织生长的最合适材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

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