Transforming Growth Factor-Beta (TGF-β) Dynamics in Thyroid Pathologies: A Comprehensive Analysis of Pre- and Post-Surgery Levels in Differentiated Thyroid Cancer and Nodular Goiter.

Polski przeglad chirurgiczny Pub Date : 2024-11-22 DOI:10.5604/01.3001.0054.8492

Adam Bednarczyk, Grzegorz Kowalski, Agata Gawrychowska, Jacek Gawrychowski

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Abstract

Introduction: In various pathological conditions, including cancer, transforming growth factor-beta (TGF-β) emerges as a pivotal cytokine.Aim: This study sought to evaluate TGF-β concentrations in blood serum samples and explore potential associations between pre- and post-surgery TGF-β levels in patients with differentiated thyroid cancer and forms of nodular goiter.Material and methods: A total of 70 patients were included, aged 26 to 79, undergoing thyroidectomy for: differentiated thyroid cancer (11), neutral nodular goiter (46), and hyperactive nodular goiter (13). Serum TGF-β1 values were assessed using the Bio-Plex Pro™ Human Cytokine Assay from Bio-Rad Laboratories, and data were analyzed with Bio-Plex Manager™ software.Conclusions: This investigation aimed to provide insights into the dynamics of TGF-β concentrations in the context of thyroid pathologies, utilizing a comparative approach before and after surgical intervention.

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转化生长因子-β (TGF-β)在甲状腺病理中的动态：分化型甲状腺癌和结节性甲状腺肿术前和术后水平的综合分析。

& lt; b>介绍:& lt; / b>在包括癌症在内的各种病理条件下，转化生长因子-β (TGF-β)作为关键的细胞因子出现。本研究旨在评估血清样本中TGF-β的浓度，并探讨分化型甲状腺癌患者手术前后TGF-β水平与结节性甲状腺肿形式之间的潜在关联。共纳入70例患者，年龄26 - 79岁，因分化性甲状腺癌（11例）、中性结节性甲状腺肿（46例）和过度活跃的结节性甲状腺肿（13例）行甲状腺切除术。使用Bio-Rad实验室的Bio-Plex Pro™人细胞因子测定法评估血清TGF-β1值，并使用Bio-Plex Manager™软件对数据进行分析。本研究旨在利用手术干预前后的比较方法，深入了解甲状腺病理背景下TGF-β浓度的动态变化。

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Polski przeglad chirurgiczny

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