Resting-state blink rate does not increase following very-light-intensity exercise, but individual variation predicts executive function enhancement levels.

IF 3.3 4区 医学 Q1 PHYSIOLOGY
Ryuta Kuwamizu, Yudai Yamazaki, Naoki Aoike, Dongmin Lee, Hideaki Soya
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Abstract

Background: Acute physical exercise, even at a very-light-intensity, potentiates prefrontal cortex activation and improves executive function. The underlying circuit mechanisms in the brain remain poorly understood, though we speculate a potential involvement of arousal-related neuromodulatory systems. Recently, our rodent study demonstrated that exercise, even at light-intensity, activates the midbrain dopaminergic neurons. Resting-state spontaneous eye blink rate is linked to brain-arousal neural circuits, and potentially to those modulated by dopaminergic system. We hypothesized that neural substrates linked to resting-state eye blink rate contribute to the cognitive impact of acute very-light-intensity exercise.

Method: We analyzed data from a previous study with a renewed focus on resting-state eye blink rate. Twenty-four healthy young adults completed both 10 min of cycling (very-light-intensity exercise: 30% peak oxygen uptake) and rest conditions. Resting-state eye blink rate and Stroop task performance were measured before and after both exercise and resting control.

Results: Results showed no significant differences in eye blink rate changes between conditions. However, correlation analyses revealed that exercise-induced changes in resting-state eye blink rate were significantly associated with individual variations in Stroop task performance enhancement.

Conclusion: Very-light-intensity exercise does not elicit a consistent increase in eye blink rate after exercise. This finding does not support the involvement of a blink increase-linked neural substrate in enhancing executive function through very-light-intensity exercise. However, resting-state eye blink rate that is altered by exercise is predictive of executive function enhancement levels; this may serve as a novel contactless biomarker for predicting exercise benefits for brain health and cognition.

静息状态眨眼频率在极低强度运动后不会增加,但个体差异可以预测执行功能的增强水平。
背景:急性体育锻炼,即使是非常低强度的,也能增强前额皮质的激活并改善执行功能。尽管我们推测与觉醒相关的神经调节系统可能参与其中,但大脑中潜在的回路机制仍然知之甚少。最近,我们对啮齿动物的研究表明,即使是低强度的运动,也能激活中脑多巴胺能神经元。静息状态下自发眨眼频率与脑觉醒神经回路有关,并可能与多巴胺能系统调节的神经回路有关。我们假设与静息状态眨眼率相关的神经基质有助于急性极轻强度运动的认知影响。方法:我们分析了先前研究的数据,重新关注静息状态下的眨眼频率。24名健康的年轻人完成了10分钟的自行车运动(极轻强度运动:30%的峰值摄氧量)和休息条件。在运动和静息控制前后分别测量静息状态眨眼率和Stroop任务表现。结果:不同条件下眨眼频率变化无显著差异。然而,相关分析显示,运动引起的静息状态眨眼频率的变化与Stroop任务性能增强的个体差异显著相关。结论:极轻强度运动并不会引起运动后眨眼频率的持续增加。这一发现不支持眨眼增加相关的神经基质参与通过极轻强度运动增强执行功能。然而,运动改变静息状态下的眨眼频率可以预测执行功能的增强水平;这可能作为一种新的非接触式生物标志物,用于预测运动对大脑健康和认知的益处。
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来源期刊
自引率
6.50%
发文量
39
期刊介绍: Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.
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