Sub2: A TFIIB Interacting Protein with Pleiotropic Roles in mRNA Synthesis, Processing and Transport.

E Fidler, A Ansari
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引用次数: 0

Abstract

The generally accepted view is that different steps of transcription, mRNA processing and mRNA trafficking are performed by dedicated accessory factors. The research during last couple of decades, however, has challenged this dogma. We recently showed that the general transcription factor TFIIB, in addition to its well established role in initiation, is also involved in termination of transcription. Mass spectrometry of purified TFIIB revealed Sub2 as one of its major interacting partners. Sub2 has already been implicated in elongation step of transcription, splicing and mRNA trafficking. Interaction of Sub2 with TFIIB implicates it in initiation and termination steps of transcription. Multiplicity of Sub2 biological roles may be responsible for its link with a number of human pathological conditions making it a potential drug target.

Sub2:在mRNA合成、加工和运输中具有多效性作用的TFIIB相互作用蛋白。
普遍接受的观点是,转录、mRNA加工和mRNA运输的不同步骤是由专门的辅助因子执行的。然而,过去几十年的研究挑战了这一教条。我们最近发现一般的转录因子TFIIB,除了在起始阶段的作用外,还参与转录的终止。纯化的TFIIB质谱分析显示Sub2是其主要的相互作用伙伴之一。Sub2已参与转录、剪接和mRNA转运的伸长步骤。Sub2与TFIIB的相互作用涉及转录的起始和终止步骤。Sub2生物学作用的多样性可能与许多人类病理状况有关,使其成为潜在的药物靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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