Role of Phenotypic Switching in the Adaptive Response of Candida tropicalis to Hyperosmotic Stress.

IF 2.7 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2025-04-02 DOI:10.1093/mmy/myaf035

Hugo Felix Perini, Cássia Milena de Souza, Eloiza Aparecida Paulo, Fernanda Tomiotto-Pellissier, Wander Rogério Pavanelli, Luciana Furlaneto-Maia, Marcia Cristina Furlaneto

引用次数: 0

Abstract

Phenotypic switching in Candida tropicalis influences virulence and fitness attributes, aiding host colonization by yeast. This study assessed the role of phenotypic switching in hyperosmotic stress adaptation. Two C. tropicalis strains (49.07 and 100.10), each with five morphotypes, were exposed to 1 M NaCl for 10 and 60 min. Results showed that 62.5% of morphotypes were less sensitive to osmotic shock, and 50% had greater osmoadaptation. The crepe morphotype exhibited less cell damage. Changes in cell wall composition, porosity, and expression of EFG1, WOR1, and HOG1 were observed. Phenotypic switching enhances osmoadaptation, impacting treatment strategies and C. tropicalis epidemiology.

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表型转换在热带假丝酵母对高渗胁迫的适应性反应中的作用。

热带假丝酵母的表型转换影响毒力和适合度属性，帮助酵母定植宿主。本研究评估了表型转换在高渗胁迫适应中的作用。结果表明，在1 M NaCl处理10和60 min后，62.5%的热带镰刀菌（49.07和100.10）对渗透冲击的敏感性较低，50%的菌株对渗透冲击的适应性较强。皱褶型细胞损伤较小。观察细胞壁组成、孔隙度及EFG1、WOR1、HOG1表达的变化。表型转换增强渗透适应，影响治疗策略和热带棘球蚴流行病学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.