A Rare Case of Adult-onset Gangliocytoma in the Parietal Lobe: Case Report and Surveillance, Epidemiology, and End Results Registry Data Analysis.

Abstract

We report a case of adult-onset gangliocytoma in the parietal lobe. A 54-year-old woman presented with sensory disturbance in her right upper limb. A computed tomography scan revealed a cystic and calcified lesion in the left parietal lobe. She underwent a left parietal craniotomy with gross total resection, and the pathological diagnosis was confirmed as gangliocytoma. Gangliocytomas are very rare tumors of the central nervous system, predominantly affecting children and young adults, and are often located in the temporal lobe. Reports of gangliocytomas developing after middle age are uncommon. To assess the epidemiology of gangliocytoma, we utilized data from the Surveillance, Epidemiology, and End Results database. From January 1, 2000, to December 31, 2021, a total of 74 cases were identified, 18 of which were in patients over 50 years of age. While 27 patients had tumors in the temporal lobe, the most frequent site, others had tumors in different locations. Notably, there were no patients over 50 with gangliocytoma in the parietal lobe in the Surveillance, Epidemiology, and End Results registry. These findings suggest that in older patients, although gangliocytomas located outside the temporal lobe are rare, they are kept in mind as one of the differential diagnoses.