Jie Deng, Yu Wang, Tianfu Qi, Zhiming Li, Hongen Zheng, Yan Wu, Lin Lu, Deyan Li, Dan Han, Wei Chen
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引用次数: 0
Abstract
Purpose: To validate the feasibility of using late iodine enhancement (LIE)-derived ECV on iodine density images using spectral detector computed tomography (SDCT; CT-ECV) and to assess the potential of CT-ECV for risk stratification among patients with non-ischemic heart failure (NIHF).
Materials and methods: Forty-five subjects who underwent cardiac SDCT and CMR were included in the validation group to calculate and compare CT-ECV with CMR-ECV to validate CT-ECV feasibility. Another 117 subjects (82 patients with NIHF, 35 controls) who underwent SDCT were included in the experimental group to explore the potential of CT-ECV for risk stratification. ECV was measured via iodine density images and CMR T1 mapping in accordance with American Heart Association 16-segment models.
Results: In the validation group, there was no significant difference between CT-ECV and CMR-ECV (P = 0.293), with an insignificant bias. In the experimental group, CT-ECV in patients with NIHF was significantly higher than in controls (P < 0.05). In 82 patients with NIHF, CT-ECV in HFrEF ( HF with reduced ejection fraction: LVEF ≤ 40%) patients was statistically higher than that of HFmEF (HF with mildly reduced ejection fraction: LVEF 41-49%) and HFpEF (HF with preserved ejection fraction: LVEF ≥ 50%) patients (P < 0.05) and a significant difference among patients with NIHF with varied New York Heart Association classes (all P < 0.05); In addition, Kaplan-Meier survival curves and Log-rank test demonstrated that NIHF patients with CT-ECV ≥ 31.29% had higher probability of MACE than NIHF patients with CT-ECV < 31.29% (P < 0.001).
Conclusion: LIE-derived CT-ECV on iodine density images using SDCT is a promising practical alternative to CMR-ECV, with the potential to assist with risk stratification among patients with NIHF.
期刊介绍：
Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.
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