Innovative approach to the detection of circulating tumor biomarkers: multi-dimensional application of liposome technology.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-04-28 DOI:10.1186/s12944-025-02578-7

Weichu Tan, Yitong Zhu, Siting Chen

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Abstract

Malignant tumors represent a significant worldwide health challenge, with elevated morbidity and mortality rates necessitating enhanced early identification and individualized treatment. Liposomes, as biomimetic lipid-based nanovesicles, have developed as a multifaceted platform for detecting and treating malignant tumors due to their excellent biocompatibility, stability, and membrane fusion properties. Circulating tumor markers, such as circulating tumor cells (CTCs), extracellular vesicles (EVs), circulating tumor proteins (CTPs), and circulating tumor nucleic acids (ctNAs), play a key role in early cancer diagnosis, disease progression monitoring, and personalized therapy. Liposome-based platforms enable effective molecular recognition, targeted detection, and signal amplification by targeting circulating tumor biomarkers, significantly increasing the potential for early tumor diagnosis and treatment. This review systematically summarizes advancements in the study of liposomes concerning circulating tumor markers, including applications in targeted recognition, early detection, and disease diagnosis, while discussing present problems and prospective applications of existing technology.

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循环肿瘤生物标志物检测的创新方法：脂质体技术的多维应用。

恶性肿瘤是一项重大的全球健康挑战，发病率和死亡率高，需要加强早期识别和个性化治疗。脂质体作为一种仿生脂基纳米囊泡，由于其优异的生物相容性、稳定性和膜融合特性，已成为检测和治疗恶性肿瘤的多方面平台。循环肿瘤标志物，如循环肿瘤细胞（ctc）、细胞外囊泡（EVs）、循环肿瘤蛋白（ctp）和循环肿瘤核酸（ctNAs），在早期癌症诊断、疾病进展监测和个性化治疗中发挥关键作用。基于脂质体的平台通过靶向循环肿瘤生物标志物，实现有效的分子识别、靶向检测和信号放大，显著提高了早期肿瘤诊断和治疗的潜力。本文系统综述了循环肿瘤标志物脂质体的研究进展，包括在靶向识别、早期检测和疾病诊断中的应用，同时讨论了现有技术存在的问题和未来的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.