Nanoparticles induced neurotoxicity.

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY
Divya Bajpai Tripathy, Subhalaxmi Pradhan, Anjali Gupta, Pooja Agarwal
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引用次数: 0

Abstract

The early development of nanotechnology has spurred major interest on the toxicity of nanoparticles (NPs) due to their ability to penetrate the biological barriers such as the BBB. This review aims at addressing how silver (AgNPs), titanium dioxide (TiO2NPs), zinc oxide (ZnONPs), iron oxide (Fe3O4NPs), carbon NPs, Copper (Cu-NPs), silicon oxide (SiO2 NPs) nanoparticles and quantum dots cause neurotoxicity. Some of the major signaling that occur are the signaling related to oxidative stress, neuroinflammation, mitochondrial dysfunction and cell equilibrium, hence results in neuronal damage and neurodegeneration. It is critical to describe that there are multiple ways by how NPs may be toxic based on their size and surface, dosage, and the recipient's age and health condition. A review on in vitro and in vivo analysis provides information about the toxic potentials of NPs and preventive measures including modification of NP surface and antioxidant treatment. The results underline the necessity of comprehensive safety assessments to allow the further utilization of nanoparticles across the economy.

纳米颗粒诱导神经毒性。
纳米技术的早期发展激发了人们对纳米颗粒(NPs)毒性的主要兴趣,因为它们能够穿透诸如血脑屏障之类的生物屏障。本文综述了银(AgNPs)、二氧化钛(TiO2NPs)、氧化锌(ZnONPs)、氧化铁(Fe3O4NPs)、碳纳米颗粒、铜(Cu-NPs)、氧化硅(SiO2 NPs)纳米颗粒和量子点是如何引起神经毒性的。发生的一些主要信号是与氧化应激、神经炎症、线粒体功能障碍和细胞平衡有关的信号,从而导致神经元损伤和神经变性。至关重要的是,根据NPs的大小和表面、剂量以及受体的年龄和健康状况,有多种方式可以说明NPs是如何有毒的。本文综述了NPs在体外和体内的毒性分析,并介绍了NPs的表面修饰和抗氧化处理等预防措施。研究结果强调了全面安全评估的必要性,以便在整个经济中进一步利用纳米颗粒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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