Hongwei He, Meng Zhong, Panxianzhi Ni, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
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引用次数: 0
Abstract
Objectives: Investigate the impact of the components in element-doped calcium phosphate ceramic/PLGA composites on bone repair outcomes in animal experiments.
Methods: Computer search of CNKI, Wanfang, Pub Med, Web of science, and EMbase databases to collect related randomized controlled animal experimental studies. Using the SYRCLE Animal Experimental Bias Risk Assessment form to evaluate research quality. The outcome measures were statistically analyzed using the Rev Man 5.4 software.
Results: Included 11 randomized controlled animal studies. Meta-analysis showed that: (1) Element doping can promote the proliferation of osteoblasts in vitro. (2) Element doping can increase the activity of ALP in cells. (3) Element doping can increase bone volume fraction. (4) Element doping can increase trabecular number.
Conclusions: Trace element doping has been found to enhance the osteogenic effect of the composite material. The type of calcium phosphate ceramics may be a significant source of heterogeneity that influences the effectiveness of bone repair in vivo.
目的：通过动物实验研究元素掺杂磷酸钙陶瓷/PLGA复合材料各组分对骨修复效果的影响。方法：计算机检索中国知网、万方、Pub Med、Web of science、EMbase等数据库，收集相关随机对照动物实验研究。使用sycle动物实验偏倚风险评估表对研究质量进行评估。结果测量采用Rev Man 5.4软件进行统计分析。结果：纳入11项随机对照动物研究。meta分析显示：(1)元素掺杂能促进体外成骨细胞的增殖。(2)元素掺杂可提高细胞内ALP的活性。(3)元素掺杂可以增加骨体积分数。(4)元素掺杂可以增加小梁数量。结论：微量元素的掺入增强了复合材料的成骨效果。磷酸钙陶瓷的类型可能是影响体内骨修复有效性的异质性的重要来源。
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