{"title":"Lead (Pb) removal and suppression of Pb-induced inflammation by Lacticaseibacillus rhamnosus A6-6.","authors":"Se-Won Lee, Jeong-Muk Lim, Hyeon-Jin Jeong, Gwang-Min Lee, Kamala-Kannan Seralathan, Jung-Hee Park, Byung-Taek Oh","doi":"10.1093/lambio/ovaf039","DOIUrl":null,"url":null,"abstract":"<p><p>Lead (Pb) contamination poses serious environmental and health risks, necessitating effective remediation and protection strategies. This study evaluates the Pb removal efficiency of Lacticaseibacillus rhamnosus A6-6 and its protective effects against Pb-induced immunotoxicity. Pb adsorption studies demonstrated that L. rhamnosus A6-6 efficiently removed Pb, primarily through peptidoglycan-mediated biosorption, following the Langmuir model. Furthermore, the immunomodulatory effects of L. rhamnosus A6-6 were assessed using RAW 264.7 macrophage-like cells, revealing its ability to mitigate Pb-induced toxicity and inflammation by suppressing pro-inflammatory cytokine expression. These findings suggest that L. rhamnosus A6-6 is a promising candidate for Pb bioremediation and immune protection. This study enhances our understanding of metal-cell interactions and highlights practical applications in environmental remediation and potential therapeutic strategies.</p>","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":"78 4","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Applied Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/lambio/ovaf039","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lead (Pb) contamination poses serious environmental and health risks, necessitating effective remediation and protection strategies. This study evaluates the Pb removal efficiency of Lacticaseibacillus rhamnosus A6-6 and its protective effects against Pb-induced immunotoxicity. Pb adsorption studies demonstrated that L. rhamnosus A6-6 efficiently removed Pb, primarily through peptidoglycan-mediated biosorption, following the Langmuir model. Furthermore, the immunomodulatory effects of L. rhamnosus A6-6 were assessed using RAW 264.7 macrophage-like cells, revealing its ability to mitigate Pb-induced toxicity and inflammation by suppressing pro-inflammatory cytokine expression. These findings suggest that L. rhamnosus A6-6 is a promising candidate for Pb bioremediation and immune protection. This study enhances our understanding of metal-cell interactions and highlights practical applications in environmental remediation and potential therapeutic strategies.
期刊介绍：
Journal of & Letters in Applied Microbiology are two of the flagship research journals of the Society for Applied Microbiology (SfAM). For more than 75 years they have been publishing top quality research and reviews in the broad field of applied microbiology. The journals are provided to all SfAM members as well as having a global online readership totalling more than 500,000 downloads per year in more than 200 countries. Submitting authors can expect fast decision and publication times, averaging 33 days to first decision and 34 days from acceptance to online publication. There are no page charges.
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