Comparison of the Correlation Between Cerebral [¹⁸F]FDG Metabolism as Assessed by Two Asymmetry Indices and Clinical Neurological Score in Patients with Ischemic Cerebrovascular Disease.

IF 3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI:10.1007/s11307-025-02002-7

Yuxin Liang, Bixiao Cui, Linlin Ye, Bin Yang, Yi Shan, Hongwei Yang, Lei Ma, Miao Zhang, Jie Lu

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引用次数: 0

Abstract

Purpose: Two types of asymmetry index (AI) have been utilized in evaluating cerebral function in ischemic cerebrovascular disease, however, few data exist on the differences between these AI measures. This study aimed to compare the two AIs in assessing PET cerebral metabolism and their correlation with clinical scales, to explore their potential value and applications in clinical settings.

Procedures: Seventy patients diagnosed with subacute and chronic ischemic stroke were retrospectively analyzed. All patients underwent 2-deoxy- 2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) PET/MR scans and were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS). Nineteen patients underwent a repeat [¹⁸F]FDG PET/MR scan one year later. Two voxel-wise AI methods, designated as AI₁ and AI₂, were calculated based on standardized uptake value ratio (SUVR). The hypometabolism on affected side assessed by different AI methods were compared. The correlations between the hypometabolism and the clinical scores were analyzed.

Results: The volume and percentage of decreased [¹⁸F]FDG metabolism assessed by AI₂ was larger than that obtained from AI₁ (all p < 0.0001). The correlation coefficients between the clinical scores and the decreased metabolism in temporal and parietal lobes assessed by AI₁ method were all higher than those from AI₂. In addition, the improved follow-up patients showed more pronounced metabolic improvement as assessed by AI₁.

Conclusions: The assessment of cerebral [¹⁸F]FDG metabolism in patients with unilateral internal carotid/middle cerebral artery steno-occlusion to reflect clinical neurological function using the AI₁ method demonstrated superior performance in comparison to the AI₂ method.

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缺血性脑血管病两种不对称指标评价脑[18F]FDG代谢与临床神经学评分的相关性比较

目的：两种不对称指数（AI）被应用于缺血性脑血管病的脑功能评估，但关于这两种不对称指数之间差异的数据很少。本研究旨在比较两种ai对PET脑代谢的评估及其与临床量表的相关性，探讨其在临床中的潜在价值和应用。方法：对70例亚急性和慢性缺血性脑卒中患者进行回顾性分析。所有患者均接受2-脱氧- 2-[18F]氟-d -葡萄糖（[18F]FDG） PET/MR扫描，并使用美国国立卫生研究院卒中量表（NIHSS）和改良Rankin量表（mRS）进行评估。19例患者一年后再次进行FDG PET/MR扫描[18F]。基于标准化摄取值比（SUVR）计算了两种体素AI方法AI1和AI2。比较不同人工智能方法评价的患侧低代谢情况。分析低代谢与临床评分的相关性。结果：AI2评估的FDG代谢[18F]减少的体积和百分比大于AI1（均p < 0.0001）。AI1法评价的颞叶和顶叶代谢下降与临床评分的相关系数均高于AI2法。此外，改善的随访患者在AI1评估中表现出更明显的代谢改善。结论：采用AI1方法评估单侧颈内动脉/大脑中动脉狭窄闭塞患者脑[18F]FDG代谢，反映临床神经功能，优于AI2方法。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.